Cancer-related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins
Intracellular
Cell type enhanced (Oligodendrocyte precursor cells, Inhibitory neurons, Hepatic stellate cells, Basal prostatic cells)
Not detected in immune cells
Cell line enhanced (HaCaT, RH-30, RPTEC TERT1, U-2 OS)
Homodimer. Interacts with DLG4; the interaction possibly being prevented by the association between NOS1 and CAPON. Forms a ternary complex with CAPON and RASD1. Forms a ternary complex with CAPON and SYN1. Interacts with ZDHHC23. Interacts with NOSIP; which may impair its synaptic location (By similarity). Interacts with HTR4 (By similarity). Interacts with SLC6A4. Interacts with VAC14 (By similarity). Interacts (via N-terminal domain) with DLG4 (via N-terminal tandem pair of PDZ domains). Interacts with SLC6A4. Forms a complex with ASL, ASS1 and SLC7A1; the complex regulates cell-autonomous L-arginine synthesis and citrulline recycling while channeling extracellular L-arginine to nitric oxide synthesis pathway (By similarity).
Calmodulin-binding, Oxidoreductase
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For Research Use Only. Not For Clinical Use.