PMEL
This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants.
Class: Class I
Antigen: gp100
Antigen Species: Human
Peptide: KTWGQYWQV
Conjugate: APC
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Class: Class I
Antigen: gp100
Antigen Species: Human
Peptide: KTWGQYWQV
Conjugate: PE
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Class: Class I
Antigen: gp100
Antigen Species: Human
Peptide: YLEPGPVTV
Conjugate: BV421
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Class: Class I
Antigen: Mouse gp100
Antigen Species: Mouse
Peptide: EGSRNQDWL
Conjugate: APC
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Class: Class I
Antigen: gp100
Antigen Species: Human
Peptide: ITDQVPFSV
Conjugate: APC
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Class: Class II
Antigen: gp100
Antigen Species: Human
Peptide: WNRQLYPEWTEAQRLD
Conjugate: BV421
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Class: Class I
Antigen: gp100
Antigen Species: Human
Peptide: YLEPAPVTA
Conjugate: BV421
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Class: Class I
Antigen: Mouse gp100
Antigen Species: Human
Peptide: EGSRNQDWL
Conjugate: PE
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Class: Class I
Antigen: gp100
Antigen Species: Human
Peptide: ITDQVPFSV
Conjugate: PE
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Class: Class I
Antigen: gp100
Antigen Species: Human
Peptide: YLEPGPVTV
Conjugate: APC
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Class: Class I
Antigen: gp100
Antigen Species: Human
Peptide: YLAPGPVTA
Conjugate: BV421
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Class: Class I
Antigen: Human gp100
Antigen Species: Human
Peptide: KVPRNQDWL
Conjugate: APC
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Class: Class I
Antigen: gp100 (mutant)
Antigen Species: Human
Peptide: IMDQVPFSV
Conjugate: APC
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Class: Class I
Antigen: gp100
Antigen Species: Human
Peptide: YLEPAPVTA
Conjugate: APC
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Class: Class II
Antigen: gp100
Antigen Species: Human
Peptide: WNRQLYPEWTEAQRLD
Conjugate: APC
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Class: Class I
Antigen: Human gp100
Antigen Species: Human
Peptide: KVPRNQDWL
Conjugate: PE
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Class: Class I
Antigen: gp100 (mutant)
Antigen Species: Human
Peptide: IMDQVPFSV
Conjugate: PE
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Class: Class I
Antigen: gp100
Antigen Species: Human
Peptide: YLAPGPVTA
Conjugate: APC
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Class: Class II
Antigen: gp100
Antigen Species: Human
Peptide: WNRQLYPEWTEAQRLD
Conjugate: PE
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Class: Class I
Antigen: gp100-intron 4
Antigen Species: Human
Peptide: VYFFLPDHL
Conjugate: APC
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Class: Class I
Antigen: gp100
Antigen Species: Human
Peptide: KVPRNQDWL
Conjugate: BV421
Compare
Class: Class I
Antigen: gp100
Antigen Species: Human
Peptide: YLEPGPVTV
Conjugate: PE
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Class: Class I
Antigen: gp100
Antigen Species: Human
Peptide: VLYRYGSFSV
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Class: Class I
Antigen: gp100-intron 4
Antigen Species: Human
Peptide: VYFFLPDHL
Conjugate: PE
Compare
Class: Class I
Antigen: gp100
Antigen Species: Human
Peptide: KTWGQYWQV
Conjugate: BV421
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Class: Class I
Antigen: gp100
Antigen Species: Human
Peptide: YLEPAPVTA
Conjugate: PE
Compare
Class: Class I
Antigen: gp100
Antigen Species: Human
Peptide: IMDQVPFSV
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Class: Class I
Antigen: gp100
Antigen Species: Human
Peptide: YLEPGPVTA
Conjugate: APC
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Class: Class I
Antigen: gp100 (Wild)
Antigen Species: Human
Peptide: ITDQVPFSV
Conjugate: BV421
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Class: Class I
Antigen: gp100
Antigen Species: Human
Peptide: YLAPGPVTA
Conjugate: PE
Compare
Class: Class I
Antigen: gp100
Antigen Species: Human
Peptide: ITDQVPFSV
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Class: Class I
Antigen: gp100 (mutant)
Antigen Species: Human
Peptide: IMDQVPFSV
Conjugate: BV421
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Class: Class I
Antigen: gp100
Antigen Species: Human
Peptide: YLEPGPVTA
Conjugate: PE
Compare
Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: ALNFPGSQK
Conjugate: PE
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Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: ITDQVPFSV
Conjugate: PE
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Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: LPKEACMEI
Conjugate: PE
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Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: AVVLASLIYR
Conjugate: APC
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Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: ALLAVGATK
Conjugate: PE
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Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: LPDGQVIWV
Conjugate: PE
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Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: HLAVIGALL
Conjugate: PE
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Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: VPLAHSSSA
Conjugate: PE
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Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: ALLAVGATK
Conjugate: PE
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Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: LPDGQVIWV
Conjugate: PE
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Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: GLGQVPLIV
Conjugate: PE
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Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: VPLAHSSSA
Conjugate: PE
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Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: ALLAVGATK
Conjugate: PE
Compare
Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: LPDGQVIWV
Conjugate: PE
Compare
Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: AMLGTHTMEV
Conjugate: PE
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Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: VPLAHSSSA
Conjugate: PE
Compare
Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: ALLAVGATK
Conjugate: PE
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Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: GPVTAQVVL
Conjugate: PE
Compare
Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: ALDGGNKHFL
Conjugate: PE
Compare
Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: TPAEVSIVV
Conjugate: PE
Compare
Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: YLEPGPVTA
Conjugate: PE
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Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: GPVTAQVVL
Conjugate: PE
Compare
Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: YLEPGPVTA
Conjugate: BV421
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Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: TPAEVSIVV
Conjugate: PE
Compare
Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: VLYRYGSFSV
Conjugate: PE
Compare
Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: EPGPVTAQV
Conjugate: PE
Compare
Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: VLYRYGSFSV
Conjugate: APC
Compare
Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: TPAEVSIVV
Conjugate: PE
Compare
Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: TITDQVPFSV
Conjugate: PE
Compare
Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: EPGPVTAQV
Conjugate: PE
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Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: LLDGTATLRL
Conjugate: APC
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Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: TPAEVSIVV
Conjugate: PE
Compare
Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: LLDGTATLRL
Conjugate: PE
Compare
Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: EPGPVTAQV
Conjugate: PE
Compare
Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: KTWGQYWQV
Conjugate: APC
Compare
Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: LPSPACQLV
Conjugate: PE
Compare
Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: YLEPGPVTA
Conjugate: APC
Compare
Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: KTWGQYWQVL
Conjugate: PE
Compare
Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: ITDQVPFSV
Conjugate: BV421
Compare
Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: LPSPACQLV
Conjugate: PE
Compare
Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: ITDQVPFSV
Conjugate: APC
Compare
Class: Class I
Antigen: PMEL
Antigen Species: Human
Peptide: KTWGQYWQV
Conjugate: PE
Compare
Derivation: Phage display library screening
Type: IgG
Application: IHC-P
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Derivation: Mouse
Species Reactivity: Human
Type: Mouse IgG1
Application: ICC, IF, IHC
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Species Reactivity: Human
Type: Mouse antibody
Application: IHC
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Species Reactivity: Human
Type: Mouse IgG
Application: FC
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Species Reactivity: Cynomolgus monkey, rat, and mouse
Type: Mouse Fab
Application: FC
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Species Reactivity: Human
Type: Mouse scFv
Application: FC
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Species Reactivity: Human
Type: Mouse IgG
Application: FC
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Species Reactivity: Cynomolgus monkey, rat, and mouse
Type: Mouse scFv
Application: FC
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Species Reactivity: Cynomolgus monkey, rat, and mouse
Type: Mouse IgG
Application: FC, FuncS
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Target: PMEL17
Linker: mc-VC (maleimidocaproyl-valine-citrulline)
Drug: MMAE (Monomethyl auristatin E)
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Species Reactivity: Human
Type: ADCC enhanced antibody
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Species Reactivity: Human
Type: Antibody
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Species Reactivity: Human
Application: Cytotoxicity assay, Function study
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Species Reactivity: Human
Type: Mouse Fab
Application: FC
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Species Reactivity: Human
Type: Mouse Fab
Application: FC
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Species Reactivity: Human
Type: Mouse scFv
Application: FC
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For Research Use Only. Not For Clinical Use.