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POLR2A
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- PE-B*07:02/Human POLR2A (TPQSNRPVM) MHC Tetramer (MHC-LC2084)
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- Class: Class I
- Antigen: POLR2A
- Antigen Species: Human
- Peptide: TPQSNRPVM
- Conjugate: PE
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- APC-B*07:02/Human POLR2A (TPQSNRPVM) MHC Tetramer (MHC-LC2085)
-
- Class: Class I
- Antigen: POLR2A
- Antigen Species: Human
- Peptide: TPQSNRPVM
- Conjugate: APC
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA.
Protein class
Human disease related genes, Metabolic proteins, RNA polymerase related proteins
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (SCLC-21H)
More Types Infomation