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TNFRSF12A
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For Research Use Only. Not For Clinical Use.
Background
The tumor-necrosis factor (TNF)-related cytokines are a superfamily of proteins that have an array of functions, including ones implicated in immune regulation and apoptosis regulation. TWEAK (TNF-like weak inducer of apoptosis) is one member of this superfamily. Fnl4, a TWEAK receptor, is a growth factor-regulated immediate-early response gene that decreases cellular adhesion to the extracellular matrix and reduces serum-stimulated growth and migration.
Protein class
Cancer-related genes, CD markers
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Basal prostatic cells, Pancreatic endocrine cells, Ductal cells, Prostatic glandular cells, Exocrine glandular cells, Urothelial cells, Basal respiratory cells, Basal keratinocytes)
Immune cell specificity
Group enriched (eosinophil, neutrophil)
Cell line specificity
Cell line enhanced (U-251 MG)
Interaction
Associates with TRAF1 and TRAF2, and probably also with TRAF3.
Molecular function
Developmental protein, Receptor
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