TNFRSF1A
This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients.
Species Reactivity: Mouse
Type: Hamster IgG
Application: FuncS, Neut
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Species Reactivity: Mouse
Type: Hamster IgG
Application: Neut, IP
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Derivation: Mouse
Species Reactivity: Human
Type: Mouse IgG2a
Application: FC, IHC, IP, Neut, FuncS
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Derivation: Phage display library
Species Reactivity: Human
Type: Rabbit IgG
Application: WB, FC
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Species Reactivity: Human
Type: Rabbit IgG
Application: Neut
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Species Reactivity: Human
Type: Mouse IgG2a
Application: FC, IHC, Neut
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Species Reactivity: Human
Type: Mouse IgG1
Application: FC, Neut
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Species Reactivity: Human
Type: Mouse IgG1
Application: WB, ELISA, Neut
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Species Reactivity: Human
Type: Mouse IgG1
Application: CyTOF, FC, WB, Neut
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Species Reactivity: Human
Type: Mouse IgG1
Application: Neut, WB
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Species Reactivity: Mouse
Type: Hamster IgG
Application: FC, ELISA, WB, IP, Neut
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Species Reactivity: Mouse
Type: Hamster IgG
Application: WB, IP, Neut
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Species Reactivity: Mouse
Type: Rat IgG2a
Application: IP, IHC, FC
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Species Reactivity: Human
Type: Mouse antibody
Application: Neut, WB
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Derivation: Phage display library
Species Reactivity: Mouse
Type: Rabbit IgG
Application: ELISA
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Species Reactivity: Human
Type: Mouse IgG1
Application: FC
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Species Reactivity: Human, Rat
Type: Mouse IgG2a
Application: FC, FuncS, IA, IP, WB
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Species Reactivity: Human, Cynomolgus monkey, Rhesus monkey
Type: Mouse IgG1
Application: FC, FuncS
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Species Reactivity: Human
Type: Mouse IgG1
Application: Neut, WB
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Species Reactivity: Human
Type: Mouse IgG
Application: WB, IP, IF, IHC
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Species Reactivity: Human, Mouse, Cynomologus
Type: Human VHH
Application: ELISA, Inhib
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Species Reactivity: Human
Type: Human IgG
Application: ELISA, Inhib, IF, FC
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Species Reactivity: Human
Type: Human scFv
Application: ELISA
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Derivation: Humanized
Species Reactivity: Human
Type: Humanized IgG
Application: ELISA, FC, Inhib, FuncS
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Species Reactivity: Human
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Species Reactivity: Human
Type: Human scFv
Application: ELISA, Inhib, IF, FC
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Species Reactivity: Cynomolgus, Mouse
Type: Human VHH
Application: ELISA, Inhib
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Species Reactivity: Human, Mouse
Type: Human VHH
Application: ELISA, Inhib
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Species Reactivity: Human, Dog
Type: Human VHH
Application: ELISA, Inhib
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Species Reactivity: Human, Mouse, Cynomologus
Type: Human VHH
Application: ELISA, Inhib
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Species Reactivity: Human, Mouse, Dog
Type: Human VHH
Application: ELISA, Inhib
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Species Reactivity: Human, Mouse
Type: Human VHH
Application: ELISA, Inhib
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Species Reactivity: Human
Type: Human VHH
Application: ELISA, Inhib
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Species Reactivity: Human
Type: Human Fab
Application: ELISA, Inhib, IF, FC
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Species Reactivity: Human
Type: Human Fab
Application: ELISA
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Derivation: Humanized
Species Reactivity: Human
Type: Human scFv
Application: ELISA, FC, Inhib
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Derivation: Humanized
Species Reactivity: Human
Type: Human scFv
Application: ELISA, FC, Inhib
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Species Reactivity: Human
Type: Human IgG
Application: ELISA
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Derivation: Humanized
Species Reactivity: Human
Type: Humanized Fab
Application: ELISA, FC, Inhib
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Derivation: Humanized
Species Reactivity: Human
Type: Humanized Fab
Application: ELISA, FC, Inhib
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Derivation: Phage display library
Species Reactivity: Human
Type: Camelid VHH
Application: ELISA
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Derivation: Humanized
Species Reactivity: Human
Type: Humanized IgG
Application: ELISA, FC, Inhib, FuncS
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Species Reactivity: Human, Rhesus monkey
Type: Humanized antibody
Application: ELISA, FC, Neut
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Species Reactivity: Human
Type: Mouse IgG2a, κ
Application: WB, FC, IHC
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Derivation: Human
Species Reactivity: Human
Type: Single Domain Antibody
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Species Reactivity: Human, Rhesus monkey
Type: Humanized Fab
Application: ELISA, FC, Neut
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Species Reactivity: Human
Type: Mouse Fab
Application: ELISA, FC, Neut
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Species Reactivity: Human, Rhesus monkey
Type: Humanized scFv
Application: ELISA, FC, Neut
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Species Reactivity: Human
Type: Mouse scFv
Application: ELISA, FC, Neut
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Scaffold Name: Kunitz domains
Target: TNFR1
Species Reactivity: Human
Derivation: Phage display
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Species Reactivity: Human
Type: Llama VHH
Application: FA, FC, ICC, ELISA
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