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    TNFRSF4

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    For Research Use Only. Not For Clinical Use.


    Background

    The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation.
    TNFRSF4
    Protein class

    Cancer-related genes, CD markers, Disease related genes, Human disease related genes

    Predicted location

    Membrane

    Single cell type specificity

    Cell type enhanced (Langerhans cells, Adipocytes, granulocytes, Endothelial cells, T-cells, Ionocytes)

    Immune cell specificity

    Group enriched (T-reg, memory CD4 T-cell, NK-cell, basophil)

    Cell line specificity

    Group enriched (MOLT-4, NB-4)

    Interaction

    Interacts with TRAF2, TRAF3 and TRAF5. (Microbial infection) Interacts with Human herpesvirus 6B/HHV-6B gQ1:gQ2 proteins.

    Molecular function

    Host cell receptor for virus entry, Receptor

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