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    TNFSF11

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    For Research Use Only. Not For Clinical Use.


    Background

    Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is a protein that in humans is encoded by the TNFSF11 gene.
    TNFSF11
    Protein class

    Cancer-related genes, CD markers, Disease related genes, FDA approved drug targets, Human disease related genes

    Predicted location

    Intracellular, Membrane, Secreted (different isoforms)

    Single cell type specificity

    Cell type enhanced (Late spermatids, Breast glandular cells, Early spermatids, Ductal cells, Breast myoepithelial cells)

    Immune cell specificity

    Immune cell enriched (NK-cell)

    Cell line specificity

    Cell line enhanced (HSkMC, NTERA-2)

    Interaction

    Homotrimer (By similarity). Interacts with TNFRSF11B (PubMed:22664871). Interacts with TNFRSF11A. Interacts with FBN1 (via N-terminal domain) in a Ca(+2)-dependent manner (By similarity). Interacts with TNFAIP6 (via both Link and CUB domains).

    Molecular function

    Cytokine, Developmental protein, Receptor

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