TNNI3
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Troponin I is useful in making a diagnosis of heart failure, and of ischemic heart disease. An elevated level of troponin is also now used as indicator of acute myocardial injury in patients hospitalized with moderate/severe Coronavirus Disease 2019 (COVID-19). Such elevation has also been associated with higher risk of mortality in cardiovascular disease patients hospitalized due to COVID-19.
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- Species Reactivity: Bovine, Canine, Feline, Goat, Human, Mouse, Porcine, Rabbit, Rat
- Type: Mouse IgG2a
- Application: ELISA, Inhib, WB
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- Species Reactivity: Bovine, Canine, Feline, Fish, Goat, Human, Mouse, Porcine, Rabbit, Rat
- Type: Mouse IgG2b
- Application: ELISA, Inhib, WB
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, Inhib, WB
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- Species Reactivity: Human
- Type: Chicken IgG
- Application: WB, IHC, IF, FuncS
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IF, IHC, IP
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ICC, IF, IHC-Fr, IHC-P, IP, WB
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: IA, IP, IHC, WB
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit Fab
- Application: ELISA
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit scFv
- Application: ELISA
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- Species Reactivity: Human
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- Species Reactivity: Human
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- Species Reactivity: Human
- Type: Human IgG1
- Application: ELISA, WB
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- Species Reactivity: Human
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: ELISA
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
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- Derivation: Mouse
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG2b
- Application: ELISA, WB
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- Derivation: Mouse
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG2a
- Application: ELISA, WB
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- Derivation: Mouse
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG2a
- Application: ELISA, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA, IHC
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- Derivation: Mouse
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG2a
- Application: ELISA, WB
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: FuncS, ELISA
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: FuncS, ELISA
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, WB, IHC, IP
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, WB, IHC, IP
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: FuncS, ELISA
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For Research Use Only. Not For Clinical Use.