Tau
Immunotherapies designed to treat neurodegenerative tauopathies that primarily engage extracellular tau may have limited efficacy as tau is primarily intracellular. We generated tau-targeting single-chain variable fragments (scFvs) and intrabodies (iBs) from the phosphorylated tau-specific antibodies CP13 and PHF1 and the pan-tau antibody Tau5. Recombinant adeno-associated virus (rAAV) was utilized to express these antibody fragments in homozygous JNPL3 P301L tau mice. Two iBs (CP13i, PHF1i) and one scFv (PHF1s) abrogated tau pathology and delayed time to severe hindlimb paralysis. In a second tauopathy model (rTg4510), CP13i and PHF1i reduced tau pathology, but cognate scFvs did not. These data demonstrate that (1) disease-modifying efficacy does not require antibody effector functions, (2) the intracellular targeting of tau with phosphorylated tau-specific iBs is more effective than extracellular targeting with the scFvs, and (3) robust effects on tau pathology before neurodegeneration only resulted in modest disease modification as assessed by delay of severe motor phenotype.
Derivation: Humanized
Species Reactivity: Human
Type: Humanized IgG
Application: ELISA, FuncS
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Species Reactivity: human, mouse, rat, bovine and monkey
Application: ELISA, dot blot, WB
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Derivation: Mouse
Type: scFv
Application: FC, Neut, Funcs
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Derivation: Mouse
Type: Fab
Application: IP, FuncS
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Derivation: Human
Type: scFv
Application: ELISA, WB, FuncS
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Derivation: Human
Type: Fab
Application: ELISA, WB, FC, FuncS
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Derivation: Human
Type: IgG
Application: WB, Neut, FuncS
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Derivation: Mouse
Type: IgG
Application: ELISA, WB, IP, FuncS
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Species Reactivity: Human, Mouse, Rat
Application: ELISA, WB
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Derivation: Human
Species Reactivity: Human
Type: Human scFv
Application: ELISA, WB, IHC, FuncS
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Derivation: Human
Species Reactivity: Human
Type: Human IgG
Application: ELISA, WB, IHC, FuncS
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Species Reactivity: Human
Type: Rabbit IgG
Application: WB
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Derivation: Mouse hybridoma cell line
Species Reactivity: Human
Type: Mouse Fab
Application: ELISA, IF
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Species Reactivity: Human
Type: Rabbit Fab
Application: WB
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Derivation: Humanized
Species Reactivity: Human
Type: Humanized scfv
Application: WB
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Derivation: Humanized
Species Reactivity: Human
Type: Humanized IgG
Application: WB
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Derivation: Humanized
Species Reactivity: Human
Type: Humanized Fab
Application: WB
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Derivation: Humanized
Species Reactivity: Human
Type: Humanized scfv
Application: WB
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Derivation: Humanized
Species Reactivity: Human
Type: Humanized IgG
Application: WB
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Derivation: Mouse hybridoma cell line
Species Reactivity: Human
Type: Mouse Fab
Application: ELISA, IF
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Derivation: Humanized
Species Reactivity: Human
Type: Humanized Fab
Application: WB
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Derivation: Humanized
Species Reactivity: Human
Type: Humanized IgG1
Application: WB, IHC, ELISA
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Derivation: Humanized
Species Reactivity: Human
Type: Humanized scfv
Application: WB, IHC, ELISA
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Derivation: Humanized
Species Reactivity: Human
Type: Humanized Fab
Application: WB, IHC, ELISA
Compare
Derivation: Humanized
Species Reactivity: Human
Type: Human scFv
Application: WB, IHC, ELISA
Compare
Derivation: Humanized
Species Reactivity: Human
Type: Humanized IgG1
Application: WB, IHC, ELISA
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Derivation: Humanized
Species Reactivity: Human
Type: Humanized Fab
Application: WB, IHC, ELISA
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Species Reactivity: Human
Type: Mouse Fab
Application: WB, ELISA, IHC
Compare
Derivation: Humanized
Species Reactivity: Human
Type: Humanized IgG1
Application: WB, IHC, ELISA
Compare
Derivation: Humanized
Species Reactivity: Human
Type: Human scFv
Application: WB, IHC, ELISA
Compare
Derivation: Humanized
Species Reactivity: Human
Type: Humanized Fab
Application: WB, IHC, ELISA
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Species Reactivity: Human
Type: Mouse Fab
Application: WB, ELISA, IHC
Compare
Derivation: Mouse hybridoma cell line
Species Reactivity: Human
Type: Mouse IgG2b
Application: IF, WB
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Derivation: Mouse hybridoma cell line
Species Reactivity: Human
Type: Mouse IgG2a
Application: ELISA, IF
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Derivation: Human
Species Reactivity: Human
Type: Human Fab
Application: ELISA
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Derivation: Mouse hybridoma cell line
Species Reactivity: Human
Type: Mouse IgG1
Application: IF, WB
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Derivation: Mouse hybridoma cell line
Species Reactivity: Human
Type: Mouse scFv
Application: ELISA, IF
Compare
Species Reactivity: Human
Type: Mouse Fab
Application: WB, ELISA, IHC
Compare
Species Reactivity: Human
Type: Mouse IgG
Application: IHC, WB
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Derivation: Mouse hybridoma cell line
Species Reactivity: Human
Type: Mouse scFv
Application: ELISA, IF
Compare
Derivation: Human
Species Reactivity: Human
Type: Human IgG
Application: ELISA
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Species Reactivity: Human
Type: Mouse IgG
Application: IHC, WB
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Derivation: Mouse hybridoma cell line
Species Reactivity: Human
Type: Mouse scFv
Application: ELISA, IF
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Species Reactivity: Human
Type: Humanized Fab
Application: WB, ELISA, IP, IHC, Neut
Compare
Species Reactivity: Human
Type: Mouse IgG
Application: IHC, WB
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Derivation: Human
Species Reactivity: Human
Type: Human scfv
Application: ELISA
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Species Reactivity: Human
Type: Mouse scFv
Application: WB, ELISA, IHC
Compare
Species Reactivity: Human
Type: Humanized IgG
Application: WB, Inhib, IHC, FuncS, IF
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Species Reactivity: Human
Type: Mouse scFv
Application: WB, ELISA, IHC
Compare
Derivation: Phage display library
Species Reactivity: Human
Application: WB, ELISA, IP, IHC
Compare
Derivation: Phage display library
Species Reactivity: Human
Application: WB, ELISA
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Species Reactivity: Human
Type: Mouse scFv
Application: WB, ELISA, IHC
Compare
Derivation: Phage display library
Species Reactivity: Human
Application: WB, ELISA
Compare
Derivation: Phage display library
Species Reactivity: Human
Application: WB, ELISA, IP, IHC
Compare
Species Reactivity: Human
Type: Humanized scFv
Application: WB, ELISA, IP, IHC, Neut
Compare
Derivation: Phage display library
Species Reactivity: Human
Application: WB, ELISA, IHC
Compare
Derivation: Phage display library
Species Reactivity: Human
Application: WB, ELISA, IP, IHC
Compare
Derivation: Phage display library
Species Reactivity: Human
Application: WB, ELISA, IP, IHC
Compare
Derivation: Phage display library
Species Reactivity: Human
Application: WB, ELISA, IP, IHC
Compare
Derivation: Mouse hybridoma cell line
Species Reactivity: Human
Type: Mouse IgG
Application: WB, ELISA, IF, IHC
Compare
Derivation: Mouse hybridoma cell line
Species Reactivity: Human
Type: Mouse Fab
Application: WB, ELISA, IF, IHC
Compare
Derivation: Phage display library
Species Reactivity: Human
Application: WB, ELISA, IP, IHC
Compare
Derivation: Mouse hybridoma cell line
Species Reactivity: Human
Application: WB, ELISA, IHC
Compare
Derivation: Mouse hybridoma cell line
Species Reactivity: Human
Application: WB, ELISA, IHC
Compare
Derivation: Mouse hybridoma cell line
Species Reactivity: Human
Type: Mouse scFv
Application: WB, ELISA, IF, IHC
Compare
Derivation: Humanized
Species Reactivity: Human
Type: Humanized antibody
Application: IF, FuncS
Compare
Derivation: Humanized
Species Reactivity: Human
Type: Humanized Fab
Application: WB, ELISA, IHC
Compare
Derivation: Mouse hybridoma cell line
Species Reactivity: Human
Application: WB, ELISA, IHC
Compare
Derivation: Mouse hybridoma cell line
Species Reactivity: Human
Application: WB, IHC
Compare
Derivation: Mouse hybridoma cell line
Species Reactivity: Human
Application: WB, ELISA, IHC
Compare
Derivation: Humanized
Species Reactivity: Human
Type: Human scFv
Application: WB, ELISA, IHC
Compare
Derivation: Mouse hybridoma cell line
Species Reactivity: Human
Application: WB, ELISA, IHC
Compare
Derivation: Mouse hybridoma cell line
Species Reactivity: Human
Application: WB, ELISA, IHC
Compare
Derivation: Mouse hybridoma cell line
Species Reactivity: Human
Application: WB, ELISA, IHC
Compare
Derivation: Mouse hybridoma cell line
Species Reactivity: Human
Application: WB, ELISA, IHC
Compare
Derivation: Mouse hybridoma cell line
Species Reactivity: Human
Application: WB, ELISA, IHC
Compare
Derivation: Mouse hybridoma cell line
Species Reactivity: Human
Application: WB, ELISA, IHC
Compare
Derivation: Mouse hybridoma cell line
Species Reactivity: Human
Application: WB, ELISA, IHC
Compare
Species Reactivity: Human
Type: Mouse Fab
Application: WB, ELISA
Compare
Species Reactivity: Human
Type: Mouse IgG2a
Application: WB, ELISA
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Species Reactivity: Human
Type: Mouse scFv
Application: WB, ELISA
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Species Reactivity: Human
Type: Mouse Fab
Application: WB, ELISA
Compare
Species Reactivity: Human
Type: Mouse IgG
Application: ELISA, IF, WB
Compare
Species Reactivity: Human
Type: Mouse scFv
Application: WB, ELISA
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Species Reactivity: Human
Type: Mouse Fab
Application: WB, ELISA
Compare
Species Reactivity: Human
Type: Mouse scFv
Application: WB, ELISA
Compare
Species Reactivity: Human
Type: Mouse IgG
Application: WB, ELISA
Compare
Species Reactivity: Human
Type: Mouse Fab
Application: WB, ELISA
Compare
Species Reactivity: Human
Type: Mouse scFv
Application: WB, ELISA
Compare
Species Reactivity: Human
Type: Mouse IgG
Application: WB, ELISA
Compare
Species Reactivity: Human
Type: Mouse Fab
Application: WB, ELISA
Compare
Species Reactivity: Human
Type: Mouse scFv
Application: WB, ELISA
Compare
Species Reactivity: Human
Type: Mouse IgG
Application: WB, ELISA
Compare
Derivation: Human
Species Reactivity: Human
Type: Human Fab
Application: ELISA, WB
Compare
Derivation: Human
Species Reactivity: Human
Type: Human scFv
Application: ELISA, WB
Compare
Derivation: Human
Species Reactivity: Human
Type: Human IgG
Application: ELISA, WB
Compare
Derivation: Human
Species Reactivity: Human
Type: Human Fab
Application: ELISA, WB
Compare
Derivation: Human
Species Reactivity: Human
Type: Human IgG
Application: ELISA, WB
Compare
Derivation: Human
Species Reactivity: Human
Type: Human scFv
Application: ELISA, WB
Compare
Derivation: Human
Species Reactivity: Human
Type: Human Fab
Application: ELISA, WB, IHC, FuncS
Compare
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