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UCHL1

The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009]
Protein class

Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Distal tubular cells, Excitatory neurons, Horizontal cells, Inhibitory neurons, Collecting duct cells, Spermatogonia)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (EFO-21, SCLC-21H, U-251 MG, U-266/84, U-87 MG)

Interaction

Monomer. Homodimer. Interacts with SNCA (By similarity). Interacts with COPS5.

Molecular function

Hydrolase, Protease, Thiol protease

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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