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USP22
Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.
Protein class
Enzymes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ATXN7L3, ENY2 and USP22 form a subcomplex required for histone deubiquitination (PubMed:18206972, PubMed:27601583). Interacts directly with ATXN7L3; leading to its recruitment to the SAGA complex (PubMed:18206972). Interacts with ATXN7L3 and weakly with ATXN7L3B (PubMed:27601583).
Molecular function
Activator, Chromatin regulator, Hydrolase, Protease, Thiol protease
More Types Infomation
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- Class: Class I
- Antigen: Ubiquitin-specific protease 22
- Antigen Species: Human
- Peptide: YIYDKDMEII
- Conjugate: PE
-
- Class: Class I
- Antigen: Ubiquitin-specific protease 22
- Antigen Species: Human
- Peptide: YIYDKDMEII
- Conjugate: APC
- Rabbit Anti-USP22 Recombinant Antibody (clone JU63-27) (MRO-1563-CN)
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, FC, IP
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: FC, ICC, IF, IP, WB
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IP
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, WB, IF, FC
- Mouse Anti-USP22 Recombinant Antibody (clone 1G4) (VS3-XY1580)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IP, IF
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For Research Use Only. Not For Clinical Use.