Disease related genes, FDA approved drug targets, Human disease related genes, Nuclear receptors, Transcription factors, Transporters
Intracellular
Cell type enhanced (Distal enterocytes, Proximal enterocytes, Undifferentiated cells)
Group enriched (non-classical monocyte, neutrophil, intermediate monocyte, myeloid DC, classical monocyte, eosinophil)
Cell line enhanced (HBEC3-KT, HDLM-2, U-937)
Homodimer in the absence of bound vitamin D3 (PubMed:11980721). Heterodimer with RXRA after vitamin D3 binding (PubMed:15225774, PubMed:11980721, PubMed:10678179). Interacts with MED1, NCOA1, NCOA2, NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes (PubMed:10866662, PubMed:15728261, PubMed:28698609, PubMed:9267036). Interacts with the corepressor NCOR1 (PubMed:28698609). Interacts with SNW1 (PubMed:9632709). Interacts with IRX4, the interaction does not affect its transactivation activity (PubMed:22323358). Interacts with CRY1 (By similarity). Interacts with CRY2 in a ligand-dependent manner (By similarity).
DNA-binding, Receptor
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For Research Use Only. Not For Clinical Use.