uPA
This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimers disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Camelid VHH
- Application: ELISA, FuncS
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- Derivation: Chimeric (rabbit/human)
- Species Reactivity: Human
- Type: Chimeric (rabbit/human) IgG1
- Application: FC
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- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, Inhib, WB, IHC
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For Research Use Only. Not For Clinical Use.