Anti-CD22 (clone 10F4v3)-MC-MMAF ADC (CAT#: ADC-212CL)

• Antibody Overview
• A118C Thio hu 10F4v3

• Clone
• 10F4v3

• Antibody Conjugation
• Thio

• Linker
• Mc (maleimidocaproyl)

• Linker Class/Description
• Class: Noncleavable linkers
  Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.

• Drug
• MMAF (Monomethyl auristatin F)

• Drug Class/Description
• Class: Auristatin
  Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

• Introduction
• CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases.
  CD22 is a sugar binding transmembrane protein, which specifically binds sialic acid with an immunoglobulin (Ig) domain located at its N-terminus. The presence of Ig domains makes CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signaling. It is also involved in the B cell trafficking to Peyer's patches in mice.

• Alternative Names
• CD22; CD22 molecule; SIGLEC2; SIGLEC-2; B-cell receptor CD22; BL-CAM; CD22 antigen; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2;

• Gene ID
• 933

• UniProt ID
• P20273

• ADC-211CL
• Anti-CD22 (clone 10F4v3)-BMPEO-DM1 ADC

• ADC-213CL
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• ADC-219CL
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• ADC-220CL
• Anti-CD22 (clone 10F4v3)-MC-MMAF ADC

• ADC-221CL
• Anti-CD22 (clone 10F4v3)-SPP-DM1 ADC

• ADC-222CL
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• ADC-228CL
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• ADC-230CL
• Anti-CD22 (clone 10F4v3)-MC-vc-PAB-MMAE ADC

• ADC-194LZY
• Anti-CD22 (clone 10F4v3)-MCC-DM1 ADC

• ADC-195LZY
• Anti-CD22 (clone 10F4v3)-mc-vc-PABC-MMAE ADC

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