Anti-Human Abeta Recombinant Antibody (Ponezumab) (CAT#: TAB-227)
Recombinant monoclonal antibody to Abeta. Ponezumab is a humanized monoclonal antibody designed for the treatment of Alzheimer's disease.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus & vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/if_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus & vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/if_selected.jpg
Figure 2 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/60_E2_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/60_E2_1_blue_red_green.jpg
Figure 3 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/61_E2_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/61_E2_1_blue_red_green.jpg
Figure 4 Cerebral cortex
(Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/157/2073_B_7_5.jpg
(Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/157/2073_B_7_5.jpg
Figure 5 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142192-APP
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142192-APP
Figure 5 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142192-APP
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142192-APP
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Humanized (from mouse)
- Type
- IgG2 - kappa
- Specificity
- Tested positive against native human antigen.
- Species Reactivity
- Human
- Applications
- WB, ELISA, IP, FC, FuncS, Neut, IF
- CAS
- 1178862-65-1
- Generic Name
- Ponezumab
- UNII
- 1TG15H1XE9
- MW
- 148.3 kDa
- Related Disease
- Alzheimer's disease (AD)
Product Property
- Purity
- >95.0% as determined by analysis by RP-HPLC.
- Storage
- Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.
Applications
- Application Notes
- The APP antibody has been reported in applications of IF, IHC, WB, Inhib.
Inhibition: Approximately 24 h prior to measurements of vasodilatory responses animals were randomly administered 10 mg/kg i.p. ponezumab or an irrelevant IgG isotype control
Target
- Alternative Names
- Ponezumab;1178862-65-1;PF-04360365;RN-1219;RN1219;9TL;Ab2;APP;amyloid beta (A4) precursor protein;AD1, Alzheimer disease;amyloid beta A4 protein;peptidase nexin II;preA4;protease nexin-II;peptidase nexin-II;beta-amyloid peptide;alzheimer disease amyloid p
- Gene ID
- 351
- UniProt ID
- P05067
Related Resources
Please refer to Ponezumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Ponezumab.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Afuco™ Anti-APP ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-227)This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to Abeta. It is a humanized monoclonal antibody designed for the treatment of Alzheimer's disease.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0341CL-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0341CL-S(P)) | ELISA, FuncS, In vivo | Mouse scFv |
| TAB-0342CL-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0342CL-S(P)) | ELISA, FuncS, In vivo | Mouse scFv |
| TAB-0764CLV-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0764CLV-S(P)) | ELISA | Mouse scFv |
| TAB-0765CLV-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0765CLV-S(P)) | ELISA | Mouse scFv |
| TAB-0766CLV-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0766CLV-S(P)) | ELISA | Mouse scFv |
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