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MHC Tetramers have emerged as an important tool for characterization of the specificity and phenotype of T cell immune response, useful in a large variety of disease and vaccine studies. Peptide-MHC multimers display an antigenic peptide in the MHC binding groove, functioning as a surrogate for recognition events that occur as part of the T cell interaction with antigen-presenting cell. The most prevalent form of multimer in use today consists of biotin-labeled pMHC displayed on streptavidin molecules, forming tetravalent complexes; so the common use of the term “tetramers” for this detection method. Since first description, MHC tetramers have become widely used for quantitation of antigen-specific T cell response. When coupled with methods that predict peptide binding to MHC molecules, tetramer analysis can be extremely useful for identifying T cell epitopes. Specifically, the application of Class I tetramers to study self antigens has also extensively developed in studies of tumor antigens. To sum up, MHC tetramer is a promising tool for research in immunology.
On the effort of our scientists, Creative Biolabs has an increasing number of peptide-MHC tetramer product collections. Also, we provide different class MHC tetramer custom service and guarantee providing MHC tetramer of high quality to meet demands.Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us.