In the field of therapeutic antibody development, Creative Biolabs has an increasing accumulation of experience and has already provided numerous comprehensive services and high-quality products for our clients all over the world. Recently we complete our list of agonistic antibody to be used in therapy-related and antibody-based researches.

Since the first application in cancer therapy, monoclonal antibody (MAb) is shown of promising therapeutic effect. In spite of classical mechanism of actions exerted by MAb, such as neutralization, blocking, CDC, ADCC, therapeutic antibody could also act as agonists of the receptors, essentially replacing the activity of the normal ligand. The agonist activity can occur when the antibody binds the receptor in a manner that mimics the binding of the physiological ligand resulting in antibody-mediated agonism. To date, much of the agonistic antibody in clinical and pre-clinical studies target TNF family members, such as OX40, CD27, 4-1BB and DR5. Specifically, there are currently at least 11 therapeutic antibodies in clinical trials which are intended to function as agonists, for example anti-CD40 antibody, CP-870893 from Pfizer, anti-DR5 antibody, Conatumumab from Amgen, and anti-GITR antibody, TRX518 from Tolerx.

To meet the need in study of therapeutic antibody of various mechanisms of actions, especially agonism, scientists in Creative Biolabs dedicated to developing the best-in-all antibody products for our clients. A list of our agonistic antibody product is presented to refer.

PRODUCT LIST

Target	Catalog No.	Target	Catalog No.	Target	Catalog No.
CD27	CBMAB-096LC	CD40	TAB-152	4-1BB	TAB-179
			CBMAB-105LC
	TAB-H74		TAB-199LC		TAB-457CQ
LTBR	CBMAB-098LC		CBMAB-106LC	MPL	CBMAB-108LC
	CBMAB-099LC		TAB-126CL		CBMAB-109LC
LTBR	CBMAB-100LC		CBMAB-107LC		CBMAB-110LC
FAS	CBMAB-103LC	OX40	CBMAB-101LC	DR4	TAB-H48
	PABC-193			DR6	TAB-631CL
DR5	CBMAB-104LC		CBMAB-102LC	GITR	TAB-629CL
	PABL-030		TAB-633CL	TSHR	PABW-172
	TAB-203	TrkB	TAB-180CQ		TAB-190CQ
	TAB-180	TrkC	TAB-183CQ		TAB-189CQ
	TAB-196		TAB-184CQ	TWEAKR	TAB-627CL
	TAB-195		TAB-185CQ	TWEAK	TAB-178
	TAB-625CL		TAB-182CQ	Tnfrsf1a	CBMAB-097LC

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