Products

Agonistic Antibody

Agonistic Antibody In the field of therapeutic antibody development, Creative Biolabs has an increasing accumulation of experience and has already provided numerous comprehensive services and high-quality products for our clients all over the world. Recently we complete our list of agonistic antibody to be used in therapy-related and antibody-based researches.

Since the first application in cancer therapy, monoclonal antibody (MAb) is shown of promising therapeutic effect. In spite of classical mechanism of actions exerted by MAb, such as neutralization, blocking, CDC, ADCC, therapeutic antibody could also act as agonists of the receptors, essentially replacing the activity of the normal ligand. The agonist activity can occur when the antibody binds the receptor in a manner that mimics the binding of the physiological ligand resulting in antibody-mediated agonism. To date, much of the agonistic antibody in clinical and pre-clinical studies target TNF family members, such as OX40, CD27, 4-1BB and DR5. Specifically, there are currently at least 11 therapeutic antibodies in clinical trials which are intended to function as agonists, for example anti-CD40 antibody, CP-870893 from Pfizer, anti-DR5 antibody, Conatumumab from Amgen, and anti-GITR antibody, TRX518 from Tolerx.

To meet the need in study of therapeutic antibody of various mechanisms of actions, especially agonism, scientists in Creative Biolabs dedicated to developing the best-in-all antibody products for our clients. A list of our agonistic antibody product is presented to refer.

PRODUCT LIST

Target Catalog No. Target Catalog No. Target Catalog No.
CD27 CBMAB-096LC CD40 TAB-152 4-1BB TAB-179
CBMAB-105LC
TAB-H74 TAB-199LC TAB-457CQ
LTBR CBMAB-098LC CBMAB-106LC MPL CBMAB-108LC
CBMAB-099LC TAB-126CL CBMAB-109LC
LTBR CBMAB-100LC CBMAB-107LC CBMAB-110LC
FAS CBMAB-103LC OX40 CBMAB-101LC DR4 TAB-H48
PABC-193 DR6 TAB-631CL
DR5 CBMAB-104LC CBMAB-102LC GITR TAB-629CL
PABL-030 TAB-633CL TSHR PABW-172
TAB-203 TrkB TAB-180CQ TAB-190CQ
TAB-180 TrkC TAB-183CQ TAB-189CQ
TAB-196 TAB-184CQ TWEAKR TAB-627CL
TAB-195 TAB-185CQ TWEAK TAB-178
TAB-625CL TAB-182CQ Tnfrsf1a CBMAB-097LC


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