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Bispecific Antibody Production

Creative Biolabs possesses enriched experience in antibody engineering and manufacture, performing various strategies to offer custom-designed recombinant antibodies. For recent years, scientists from Creative Biolabs are devoted to developing bispecific antibodies (BsAbs) with high controllability and operability.

Figure: Various bispecific antibodies (Drug Discov Today, 2015)

BsAbs are artificial antibodies that have defined specificities and can bind to two different antigens or epitopes. They have been proven to be effective as therapeutic agents and widely researched in scientific or clinical purpose. We leverage different technological approaches to generate BsAbs of different formats. And according to the antibody srructure, BsAbs and other bispecific immunotherapeutics that we can provide are claasified into five major groups: bispcific IgGs, appended IgGs, BsAb fragments, bispecific fusion proteins and BsAb conjugates.

With novel straegies and proprietary Creative Discovery Platform™, Creative Biolabs can adjust the format, valency, flexibility and half-life of BsAbs to meet every client`s requirements.

Roland E. Kontermann and Ulrich Brinkmann. Bispecific antibodies. Drug Discov Today. 2015 Jul; 20(7):838-47.

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