Anti-Human IL6 Recombinant Antibody (Sirukumab) (CAT#: TAB-097)

Recombinant monoclonal antibody to IL6. Sirukumab (CNTO 136) is a human monoclonal antibody designed for the treatment of rheumatoid arthritis.


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Figure 1 Mean (SD) serum sirukumab concentration versus time after multiple subcutaneous administrations of sirukumab in (A) Part A and (B) Part B and mean per cent change from baseline in serum concentrations of C-reactive protein (CRP) in (C) Part A and (D) Part B.

Figure 1 Mean (SD) serum sirukumab concentration versus time after multiple subcutaneous administrations of sirukumab in (A) Part A and (B) Part B and mean per cent change from baseline in serum concentrations of C-reactive protein (CRP) in (C) Part A and (D) Part B.

Data from one of the study sites that participated in Part A were excluded from all pharmacokinetics and pharmacodynamics analyses due to questionable data integrity. Serum sirukumab concentrations were plotted starting on day 2 (Part A) and day 5 (Part B).

Smolen, J. S. , Weinblatt, M. E. , Sheng, S. , Zhuang, Y. , & Hsu, B. . (2014). Sirukumab, a human anti-interleukin-6 monoclonal antibody: a randomised, 2-part (proof-of-concept and dose-finding), phase ii study in patients with active rheumatoid arthritis despite methotrexate therapy. Annals of the Rheumatic Diseases, 73(9), 1616-1625.


Specifications

  • Immunogen
  • Recombinant full length protein (Human).
  • Host Species
  • Human
  • Derivation
  • Human
  • Type
  • IgG1 - kappa
  • Specificity
  • Tested positive against native human antigen.
  • Species Reactivity
  • Human
  • Applications
  • FC, IP, ELISA, Neut, FuncS, IF, WB
  • CAS
  • 1194585-53-9
  • Generic Name
  • Sirukumab
  • MW
  • 144.6 kDa
  • Related Disease
  • Rheumatoid arthritis (RA) (Despite Methotrexate Therapy)

Product Property

  • Purity
  • >95.0% as determined by analysis by SDS-PAGE.
  • Storage
  • Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.

Applications

  • Application Notes
  • The IL6 antibody has been reported in applications of PK.

Target

  • Alternative Names
  • Sirukumab;1194585-53-9;CNTO 136;AME-19A;IL6;interleukin 6 (interferon, beta 2);IFNB2;interleukin-6;BSF2;HGF;HSF;IL 6;CDF;BSF-2;IFN-beta-2;interferon beta-2;interleukin BSF-2;hybridoma growth factor;CTL differentiation factor;B-cell stimulatory factor 2;B-

Related Resources

  • Biosimilar Overview
  • Related Diseases
  • Related Signaling Pathways
Please refer to Sirukumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Sirukumab.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Sirukumab"

Afuco™ Anti-IL6 ADCC Recombinant Antibody (Sirukumab), ADCC Enhanced
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to IL6. Sirukumab (CNTO 136) is a human monoclonal antibody designed for the treatment of rheumatoid arthritis.

See other products for "IL6"

Humanized Antibody

CAT Product Name Application Type
TAB-253 Anti-Human IL-6 Recombinant Antibody (Olokizumab) WB, ELISA, FC, IP, FuncS, IF, Neut IgG4 - kappa
TAB-0172CL-S(P) Human Anti-IL6 Recombinant Antibody; scFv Fragment (TAB-0172CL-S(P)) ELISA, Block, In vivo Human scFv
TAB-0173CL-S(P) Human Anti-IL6 Recombinant Antibody; scFv Fragment (TAB-0173CL-S(P)) ELISA, Block, In vivo Human scFv
TAB-678LC-S(P) Anti-human IL6 scFv Fragment (BA399) ELISA, FC Humanized antibody
TAB-678LC-F(E) Anti-human IL6 Fab Fragment (BA399) ELISA, FC Humanized antibody

Chimeric Antibody

CAT Product Name Application Type
TAB-0026CL Human Anti-IL6 Recombinant Antibody (TAB-0026CL) Elisa, In vivo, FuncS, Block Chimeric (mouse/human) IgG
TAB-0026CL-S(P) Mouse Anti-IL6 Recombinant Antibody; scFv Fragment (TAB-0026CL-S(P)) Elisa, In vivo, FuncS, Block Mouse scFv
TAB-0026CL-F(E) Human Anti-IL6 Recombinant Antibody; Fab Fragment (TAB-0026CL-F(E)) Elisa, In vivo, FuncS, Block Chimeric (mouse/human) Fab
TAB-670LC-S(P) Anti-human IL6 scFv Fragment (NTS) ELISA Chimeric antibody (mouse/human)
TAB-670LC-F(E) Anti-human IL6 Fab Fragment (NTS) ELISA Chimeric antibody (mouse/human)

Fab Glycosylation

CAT Product Name Application Type
Gly-037LC Recombinant Anti-Human IL6 Antibody (Fab glycosylation) ELISA Humanized antibody

Deglycosylated Antibody (Non-glycosylated IgGs)

CAT Product Name Application Type
Gly-197LC Recombinant Anti-Human IL6 Antibody (Non-glycosylated) ELISA Humanized antibody

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0284MZ Chicken Anti-Interleukin-6 Polyclonal IgY WB, Indirect ELISA Chicken antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-1474CQ Rat Anti-Il6 Recombinant Antibody (clone 32C11) Block, ELISA, WB Rat IgG2a

MHC Tetramer for Cancer

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-239 Afuco™ Anti-IL6 ADCC Recombinant Antibody (Elsilimomab), ADCC Enhanced FuncS, IF, Neut, ELISA, FC ADCC enhanced antibody
AFC-TAB-097 Afuco™ Anti-IL6 ADCC Recombinant Antibody (Sirukumab), ADCC Enhanced FC, IP, ELISA, Neut, FuncS, IF ADCC enhanced antibody
AFC-TAB-H26 Afuco™ Anti-IL6 ADCC Recombinant Antibody (Enlimomab), ADCC Enhanced Neut, ELISA, IF, IP, FuncS, FC ADCC enhanced antibody
AFC-TAB-253 Afuco™ Anti-IL6 ADCC Recombinant Antibody (Olokizumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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