Recombinant monoclonal antibody to IL-6. Olokizumab is an immunomodulator. It binds to interleukin 6.
Figure 1 Olokizumab in cell assays to assess neutralization of IL-6 activity.
(A) Cis-signaling: Primary human hepatocytes were cultured in collagen-coated plates and stimulated with IL-6 (12.5 ng/mL) in the presence or absence of olokizumab (titration from 10 µg/mL) for 72 h. Cell supernatants were analyzed for acute phase proteins CrP and SAA using a Luminex kit. Data are plotted with standard errors of means from triplicate determinations in three experiments. (B) Trans-signaling: Different concentrations of olokizumab were pre-incubated with IL-6 at 25ng/mL followed by addition of soluble IL-6 receptor gp80 at 125 ng/mL. This complex was added to prepared HUVeC cells and incubated at 37 °C for 20 min to allow IL-6-induced STAT-3 phosphorylation to occur. The activation was stopped by the addition of ice-cold lysis buffer, and cell supernatants were analyzed for STAT3 phosphorylation using a MSD STAT-3 kit. Data are plotted with standard errors of means from triplicate determinations in two experiments.
Shaw, S. , Bourne, T. , Meier, C. , Carrington, B. , Gelinas, R. , & Henry, A. , et al. (2014). Discovery and characterization of olokizumab. mAbs, 6(3), 773-781.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Afuco™ Anti-IL6 ADCC Recombinant Antibody (Olokizumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to IL-6. Olokizumab is an immunomodulator. It binds to interleukin 6.
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0026CL | Human Anti-IL6 Recombinant Antibody (TAB-0026CL) | Elisa, In vivo, FuncS, Block | Chimeric (mouse/human) IgG |
TAB-0026CL-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (TAB-0026CL-F(E)) | Elisa, In vivo, FuncS, Block | Chimeric (mouse/human) Fab |
TAB-670LC | Anti-human IL6 Recombinant Antibody (NTS) (TAB-670LC) | ELISA, Inhib | Chimeric antibody (mouse/human) |
TAB-670LC-F(E) | Anti-human IL6 Fab Fragment (NTS) | ELISA | Chimeric antibody (mouse/human) |
VS3-WK1519 | Human Anti-IL6 Recombinant Antibody (clone CLLB8) | ELISA, FC | Chimeric (mouse/human) IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0171CL | Mouse Anti-IL6 Recombinant Antibody (TAB-0171CL) | ELISA, Block, In vivo | Mouse IgG |
TAB-0022CL-S(P) | Mouse Anti-IL6 Recombinant Antibody; scFv Fragment (TAB-0022CL-S(P)) | Elisa, In vivo, FuncS, Block | Mouse scFv |
TAB-0023CL-S(P) | Mouse Anti-IL6 Recombinant Antibody; scFv Fragment (TAB-0023CL-S(P)) | Elisa, In vivo, FuncS, Block | Mouse scFv |
TAB-0171CL-F(E) | Mouse Anti-IL6 Recombinant Antibody; Fab Fragment (TAB-0171CL-F(E)) | ELISA, Block, In vivo | Mouse Fab |
TAB-669LC-S(P) | Anti-human IL6 scFv Fragment (SK2) | ELISA |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0172CL | Human Anti-IL6 Recombinant Antibody (TAB-0172CL) | ELISA, Block, In vivo | Human IgG |
TAB-0173CL | Human Anti-IL6 Recombinant Antibody (TAB-0173CL) | ELISA, Block, In vivo | Human IgG1 |
TAB-0172CL-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (TAB-0172CL-F(E)) | ELISA, Block, In vivo | Humanized Fab |
TAB-0173CL-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (TAB-0173CL-F(E)) | ELISA, Block, In vivo | Humanized Fab |
TAB-678LC-S(P) | Anti-human IL6 scFv Fragment (BA399) | ELISA, FC | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0174CL-S(P) | Human Anti-IL6 Recombinant Antibody; scFv Fragment (TAB-0174CL-S(P)) | ELISA, Block, In vivo | Human scFv |
TAB-0175CL-S(P) | Human Anti-IL6 Recombinant Antibody; scFv Fragment (TAB-0175CL-S(P)) | ELISA, Block, In vivo | Human scFv |
TAB-0176CL-S(P) | Human Anti-IL6 Recombinant Antibody; scFv Fragment (TAB-0176CL-S(P)) | ELISA, Block, In vivo | Human scFv |
TAB-671LC-F(E) | Anti-human IL6 Fab Fragment (SK2a) | ELISA | Human antibody |
TAB-680LC-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (TAB-680LC-F(E)) | ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PABC-232 | Camelid Anti-IL6 Recombinant Antibody (PABC-232) | ELISA | Camelid IgG |
HPAB-0030LY | Humanized Anti-IL6 Recombinant Antibody (HPAB-0030LY) | WB | Humanized IgG4 |
MRO-0833-CN | Mouse Anti-IL6 Recombinant Antibody (clone 1-6) | WB, IHC, IF | Mouse IgG2b |
MRO-0834-CN | Mouse Anti-IL6 Recombinant Antibody (clone 11-D4) | WB, IHC, IF, ELISA | Mouse IgG1 |
MRO-0835-CN | Mouse Anti-IL6 Recombinant Antibody (clone 7-A7) | WB, IHC | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-037LC | Recombinant Anti-Human IL6 Antibody (Fab glycosylation) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-197LC | Recombinant Anti-Human IL6 Antibody (Non-glycosylated) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0284MZ | Chicken Anti-Interleukin-6 Polyclonal IgY | WB, Indirect ELISA | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1465CQ | Mouse Anti-IL6 Recombinant Antibody (VMC201) | Neut, WB, IHC | Mouse IgG2 |
NEUT-1466CQ | Mouse Anti-IL6 Recombinant Antibody (clone CBL224) | IHC, ELISA, Neut | Mouse IgG1 |
NEUT-1467CQ | Mouse Anti-IL6 Recombinant Antibody (clone CBL260), FITC | FC, Neut | Mouse IgG1 |
NEUT-1468CQ | Mouse Anti-IL6 Recombinant Antibody (clone CBL414) | WB, IHC, ELISA, Neut | Mouse IgG1 |
NEUT-1469CQ | Rat Anti-IL6 Recombinant Antibody (clone CBL888) | ELISA, FC, IF, IP, Neut, WB | Rat IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1474CQ | Rat Anti-Il6 Recombinant Antibody (clone 32C11) | Block, ELISA, WB | Rat IgG2a |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1814 | Rabbit Anti-IL6 Recombinant Antibody (clone DS1814AB) | WB | Rabbit IgG |
MOR-4277 | Rabbit Anti-IL6 Recombinant Antibody (clone SI360DS) | ELISA | Rabbit IgG |
MOR-4622 | Rabbit Anti-IL6 Recombinant Antibody (clone TH135DS) | WB, ELISA | Rabbit IgG |
MOR-4623 | Rabbit Anti-IL6 Recombinant Antibody (clone TH136DS) | WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-LC3429 | PE-B8/Human IL6 (ILKQKIALD) MHC Tetramer | FCM | |
MHC-LC3430 | APC-B8/Human IL6 (ILKQKIALD) MHC Tetramer | FCM |
CAT | Product Name | Application | Type |
---|---|---|---|
NS-043CN | Human Anti-IL6 Recombinant Antibody (NS-043CN) | ELISA, WB | Human IgG1 |
NS-043CN-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (NS-043CN-F(E)) | ELISA, WB | Human Fab |
NS-043CN-S(P) | Human Anti-IL6 Recombinant Antibody; scFv Fragment (NS-043CN-S(P)) | ELISA, WB | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0824-CN-F(E) | Human Anti-IL6 Recombinant Antibody (clone Ab18); Fab Fragment | ELISA | Human Fab |
HPAB-0825-CN-F(E) | Human Anti-IL6 Recombinant Antibody (clone 18E); Fab Fragment | ELISA | Human Fab |
HPAB-0164-YJ-F(E) | Mouse Anti-IL6 Recombinant Antibody (clone 6yl-9); Fab Fragment | ELISA, WB, Inhib, Neut | Mouse Fab |
HPAB-1250-FY-S(P) | Mouse Anti-IL6 Recombinant Antibody; scFv Fragment (HPAB-1250-FY-S(P)) | ELISA | Mouse scFv |
HPAB-1251-FY-S(P) | Mouse Anti-IL6 Recombinant Antibody; scFv Fragment (HPAB-1251-FY-S(P)) | ELISA | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0030LY-S(P) | Humanized Anti-IL6 Recombinant Antibody; scFv Fragment (HPAB-0030LY-S(P)) | WB | scFv |
HPAB-AP715-YC-S(P) | Rabbit Anti-IL6 Recombinant Antibody; scFv Fragment (HPAB-AP715-YC-S(P)) | ELISA, Block | Rabbit scFv |
HPAB-AP716-YC-S(P) | Rabbit Anti-IL6 Recombinant Antibody; scFv Fragment (HPAB-AP716-YC-S(P)) | ELISA, Block | Rabbit scFv |
HPAB-S0077-YC-S(P) | Human Anti-IL6 Recombinant Antibody; scFv Fragment (HPAB-S0077-YC-S(P)) | ELISA, Block | Human scFv |
HPAB-S0083-YC-S(P) | Rabbit Anti-IL6 Recombinant Antibody; scFv Fragment (HPAB-S0083-YC-S(P)) | ELISA, Block | Rabbit scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-239 | Afuco™ Anti-IL6 ADCC Recombinant Antibody (Elsilimomab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-097 | Afuco™ Anti-IL6 ADCC Recombinant Antibody (Sirukumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
AFC-TAB-H26 | Afuco™ Anti-IL6 ADCC Recombinant Antibody (Enlimomab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
AFC-TAB-253 | Afuco™ Anti-IL6 ADCC Recombinant Antibody (Olokizumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-S0166-YC | Camelid Anti-IL6 Recombinant Single Domain Antibody (clone 6D5) | ELISA | Camelid VHH |
HPAB-S0167-YC | Camelid Anti-IL6 Recombinant Single Domain Antibody (clone 8F2) | ELISA | Camelid VHH |
HPAB-S0168-YC | Camelid Anti-IL6 Recombinant Single Domain Antibody (clone 6B12) | ELISA, Inhib | Camelid VHH |
HPAB-S0169-YC | Camelid Anti-IL6 Recombinant Single Domain Antibody (clone 7G4) | ELISA, Inhib | Camelid VHH |
HPAB-S0170-YC | Camelid Anti-IL6 Recombinant Single Domain Antibody (clone 7G5) | ELISA, Inhib | Camelid VHH |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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