Colorectal cancer (CRC) remains a leading cause of cancer-related deaths worldwide, with the likelihood of distant metastasis to the liver or lungs adding to the challenges of CRC treatment. Currently, surgical resectionRead More…
A Breakthrough in Influenza Defense: Discovering Antibodies for Broad-Spectrum Protection
The titers of antibodies that inhibit the receptor binding of hemagglutinin (HA), a key viral protein of the influenza virus, are widely recognized as directly related to protecting organisms against infection. Recently,Read More…
Discovery of Highly Neutralizing Human Antibodies Targeting Pseudomonas aeruginosa for Treatment of Drug-Resistant Infections
Pseudomonas aeruginosa possesses multiple mechanisms of antibiotic resistance, leading to high morbidity and mortality rates. It may result in complex infections and dangerous septic cases in critically ill patients. In a recentRead More…
Two New Strategies Targeting Siglec-7 Show Promise in Treating Ovarian Cancer
Ovarian cancer is often diagnosed in advanced stages, and its resistance to existing treatment methods poses a significant challenge. According to data from the National Institutes of Health (NIH) in the UnitedRead More…
Researchers Revealed the Feasibility and Clinical Prospects of Targeting SLC7A11 for the Treatment of Osteosarcoma
Osteosarcoma (OS) is the most common malignant bone tumor, primarily affecting adolescents. In the 1970s, the clinical use of chemotherapy in conjunction with surgical resection significantly improved the five-year survival rate ofRead More…
Controlling Widespread Neutralizing Antibodies Produced in Post-Treatment Controllers Promotes Long-Term Remission of HIV-1 Infection
Some HIV-1 carriers who received early antiretroviral therapy (ART) for several years can maintain long-term control over the virus after treatment interruption. However, the mechanism behind this post-treatment control is not fullyRead More…
Scientists Identify Special Genes Capable of Producing a Large Number of Key Antibodies
Cellular secretions play various crucial roles within the body. However, methods to connect this functional information with surface markers and the transcriptome have been lacking. In a recent research paper published inRead More…
Targeting Integrins for the Treatment of Drug-Resistant Acute Myeloid Leukemia
Acute myeloid leukemia (AML) remains highly resistant to treatment with a high relapse rate, necessitating the development of new therapeutic strategies. Integrin-targeted therapy, which has been extensively studied in solid tumors andRead More…
The Roles of Loss of CXCR2 Expression/Activity in Melanoma Tumorigenesis
Chemokines and their receptors have been shown to play crucial roles in regulating tumor growth, progression, metastasis, and response to immunotherapy. Initially known for their role as chemoattractants in guiding leukocyte migration,Read More…
Targeting PD-L2-RGMb Promises to Enhance the Efficacy of Cancer Immunotherapy
Immunotherapy has revolutionized the treatment of many cancer types. However, for reasons that remain poorly understood, not all patients respond equally from these potent therapies. In a recent study, researchers from HarvardRead More…