The discovery and development process of traditional antibodies is typically time-consuming, costly, and yields limited quantities. To address these challenges, Creative Biolabs has launched high-throughput antibody production services, delivering quality antibody products to clients worldwide efficiently and rapidly. Till now, our platform has been meticulously constructed to encompass a broad range of antibody formats, from single-domain antibodies to full-length IgGs.

High Throughput Antibody Platform

Recently, Creative Biolabs leverages modern biotechnology and automated equipment, combined with large-scale screening techniques, to efficiently produce antibody services. We offer effective and flexible antibody development solutions that save clients time and reduce costs, while also enhancing the success rate of antibody research and development.

Our High-throughput antibody production platform enables clients to generate a diverse range of antibodies simultaneously, allowing for rapid screening and selection of the most promising candidates. Meanwhile, we can produce large quantities of antibodies in a significantly shorter timeline. Technically, we utilize efficient yeast or mammalian cell expression systems to ensure the accurate folding and modification of antibodies. Additionally, through high-throughput screening techniques, we can rapidly assess the characteristics of these antibodies, including their affinity, specificity, and stability. This critical data not only assists clients in selecting the best candidate antibodies but also provides a solid foundation for subsequent drug development and clinical applications.

Fig.1 High Throughput Antibody Production Strategies.^1,3

Services

Creative Biolabs employs artificial intelligence (AI) algorithms to optimize the antibody screening process, efficiently displaying a vast array of antibody variants using phage display methods. Also, we use single B-cell technology for the individual analysis of each antibody. This integration allows us to swiftly identify and validate promising antibody candidates with excellent binding capabilities. Furthermore, our high-throughput platform enables comprehensive evaluation of antibody affinity and specificity, ensuring that each antibody is a high-quality product that has undergone rigorous selection.

• High Throughput Antibody Production for Single B Cell Antibody Discovery

At Creative Biolabs, our single B cell antibody discovery service utilizes state-of-the-art techniques to isolate and produce antibodies from individual B cells. By employing advanced microfluidics and high-throughput screening technologies, we efficiently identify and clone specific antibodies from a wide range of immune repertoires. Our solutions allow for the rapid development of monoclonal antibodies with high specificity and affinity, significantly reducing the time from discovery to application. Meanwhile, our streamlined workflow ensures that clients receive high-quality antibodies customized to their unique requirements, whether for research, diagnostics, or therapeutic use. Moreover, with our expertise in single B cell isolation, we greatly enhance the likelihood of discovering novel and effective antibodies, providing our clients with a competitive advantage in their projects.

• High Throughput Antibody Production for Phage Display-mediated Antibody Discovery

In our labs, our scientists improve the powerful capabilities of phage display technology, facilitating the selection and optimization of antibodies from extensive libraries. In our advanced process, numerous antibody fragments can be displayed on the surface of bacteriophages and screened against specific targets to identify high-affinity candidates. Our services can significantly accelerate the discovery process while increasing the diversity of the antibody repertoire. Furthermore, by incorporating automated liquid handling systems and sophisticated bioinformatics tools, Creative Biolabs streamlines the entire workflow—from library construction to screening and validation—ensuring consistent and reliable results. Therefore, all clients can quickly obtain antibodies specific to a variety of applications, ranging from therapeutic development to enhancing diagnostic tools.

• Artificial Intelligence-Driven Antibody Discovery Services

Our AI-driven antibody discovery services use a wide variety of AI models to optimize the regular antibody development process, making it faster and more precise. By employing advanced machine learning algorithms and extensive datasets, we can effectively predict the most promising candidates for antibody generation, thereby significantly decreasing the time and resources usually involved. Our AI models meticulously analyze biological data to identify potential epitopes and enhance antibody affinity and specificity before experimental validation. These models not only speed up the discovery phase but also offer chances of successful therapeutic outcomes. With our AI-driven service, clients can anticipate a new standard of efficiency in their antibody development projects, paving the way for groundbreaking therapeutic solutions.

Fig.2 The Screening Efficiency Analysis for Single-cell Platform-based BsAb.^2,3

Advantages

• High Efficiency and Rapid Screening: Our high-throughput technology allows for simultaneous experimentation across multiple samples, significantly enhancing the speed of antibody selection.
• Cost-Effectiveness: Although the initial investment in equipment may be substantial, our high-throughput platform greatly reduces the cost of developing each antibody in the long run by minimizing the number of experiments and the amount of reagents used.
• Broad Diversity: By employing high-throughput screening, Creative Biolabs can obtain candidate antibodies from a larger and more diverse antibody library, increasing the likelihood of discovering effective antibodies.
• Enhanced Optimization Capabilities: High-throughput technology enables the parallel optimization of various antibody parameters, such as affinity, specificity, and stability, facilitating the faster identification of optimal antibody variants.
• Automation and Standardization: High-throughput techniques automate the experimental process, reducing variability introduced by human factors, while also achieving standardization that enhances data consistency and reproducibility.
• Data Processing Capability: High-throughput technologies generate vast amounts of data, and when combined with advanced data analysis methods, our staff can extract valuable insights more effectively, accelerating the antibody development research process.
• Robust Adaptability: Our high-throughput technology integrates seamlessly with other methodologies, such as artificial intelligence, phage display, and single B-cell sequencing, making the antibody development process more comprehensive and efficient.

Creative Biolabs' high-throughput antibody production service combines advanced artificial intelligence technology, phage display technology, and single B cell technology to offer clients faster and more flexible antibody screening and production solutions. At the heart of our service is a powerful and scalable platform that enables us to produce a wide variety of recombinant antibodies at an unprecedented speed. Our high-throughput platform not only accelerates the discovery phase but also significantly increases the chances of identifying high-affinity antibodies that specifically target the desired antigens. Please feel free to contact us.

References

1. Lu, Ruei-Min, et al. "Development of therapeutic antibodies for the treatment of diseases." Journal of bioBiomedical Science (2020): 1-30.
2. Segaliny, Aude I., et al. "A high throughput bispecific antibody discovery pipeline." Communications Biology 6.1 (2023): 380.
3. Distributed under Open Access license CC BY 4.0, without modification.

For research use only. Not intended for any clinical use.