Creative Biolabs provides a diverse range of engineered antibody products, dedicated to providing clients with effective, precise, and safe antibody solutions. Our products use advanced antibody screening and engineering techniques, ensuring each one has exceptional specificity for accurately identifying targets while minimizing interference from non-specific binding. Through affinity optimization, our antibodies demonstrate enhanced biological activity even at low concentrations, thereby increasing the sensitivity and reliability of experiments.

Introduction

Engineered antibody products play a crucial role in the fields of modern medicine and biotechnology. Through engineering techniques, the specificity and affinity of antibodies toward specific antigens can be enhanced, thereby improving their therapeutic and detection efficacy. Moreover, optimizing the structure of antibodies can increase their stability, leading to improved tolerability under various environmental conditions and extended half-life in the body. Furthermore, antibody engineering endows antibodies with diverse functionalities, enabling them to not only neutralize pathogens but also activate the immune system or direct cell-mediated cytotoxicity against tumor cells. This opens up vast possibilities for therapeutic applications, particularly in the realm of cancer immunotherapy.

As the use of antibodies becomes increasingly widespread, Creative Biolabs remains dedicated to the development and enhancement of a variety of innovative antibody products to meet the evolving demands of research. We presently offer three main categories of groundbreaking products: antibody-drug conjugates (ADCs), bispecific antibodies, and glyco-engineered antibodies. Each product line reflects our company's exceptional capabilities in research and development as well as our deep understanding of customer needs.

Fig.1 Engineered Antibody Formats.^1,3

Products

Glycoengineering Antibody

At Creative Biolabs, glycoengineering of antibodies is a cutting-edge approach that boosts therapeutic effectiveness by altering the glycosylation patterns of antibodies to improve their biological function and stability. Creative Biolabs leads the way in glycan engineering technology, offering the capability to finely tune the glycoform profiles of antibodies. In our labs, we enhance immunogenicity and increase the affinity and specificity of antibodies by optimizing their glycosylation patterns. Furthermore, our products demonstrate significant stability during metabolic activity, resulting in longer half-lives.

Bispecific Antibody

Bispecific antibodies are an innovative class of engineered antibodies capable of simultaneously targeting two different antigens, demonstrating significant potential in the treatment of various diseases. Creative Biolabs has developed an advanced platform for the design and production of bispecific antibodies, allowing for rapid and flexible responses to market demands and providing customized solutions to meet diverse client needs. Our bispecific antibody products effectively target tumor cells and immune cells, activating the body's immune system to significantly enhance cancer treatment outcomes. Furthermore, these products are not only applicable to tumor immunotherapy but can also be extended to autoimmune diseases and other pathological conditions, showcasing a broad range of indications and therapeutic opportunities.

Antibody-drug Conjugate (ADC)

ADCs represent an innovative class of biopharmaceuticals that combine antibodies with cytotoxic agents. This approach allows for targeted destruction of tumor cells by specifically recognizing tumor antigens. Our ADC products are characterized by their high specificity, effectively targeting unique antigens on the surface of tumor cells while minimizing damage to normal cells, thereby reducing side effects. Meanwhile, through the optimization of linkers and cytotoxic compounds, we have enhanced the therapeutic efficacy and anti-tumor activity of our drugs, leading to more pronounced treatment outcomes. In addition, our ADC products have demonstrated impressive results in various assays, earning the trust of many customers.

Fig.2 Characterization of an IgG-based Bispecific Antibody.^2,3

Features

• High Specificity and Affinity: Engineered antibodies can achieve enhanced specificity and affinity through meticulous design and selection, improving their binding capability to target antigens and ultimately increasing therapeutic efficacy.
• High Stability: Modified antibodies typically exhibit improved stability, allowing them to retain activity under various conditions and prolonging their shelf life and usability.
• Multifunctionality: Through diverse construction methods, engineered antibodies can achieve multifunctionality, such as drug conjugation or binding with other molecules, expanding their applications in both therapy and diagnostics.
• Customization: Gene engineering techniques enable the tailoring of antibody characteristics to meet specific requirements, thereby offering the potential for personalized medicine.
• Design of Epitopes: Engineered antibodies can be specifically designed and optimized to target particular epitopes, enhancing their effectiveness in various applications, such as cancer or viral therapies.
• Reduced Immunogenicity: Through engineering modifications, antibodies can minimize interactions with the host's immune system, reducing immunogenicity, lessening adverse reactions, and enhancing the safety of treatments.

Utilizing our unique antibody engineering technology platform, Creative Biolabs is capable of quickly and effectively screening, optimizing, and manufacturing antibodies, resulting in high-quality engineered antibody products. We provide customized antibody engineering services that meet the precise needs of our clients, allowing them to reach their project objectives promptly and improve research efficiency. We warmly encourage you to contact us for additional details regarding our engineered antibody products.

For research use only. Not intended for any clinical use.