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Anti-FN1 × Anti-m679 Bispecific Antibody (TAND-L060)

Recombinant Anti-FN1 × Anti-HSG Bispecific Antibody (TandAb) is a bispecific fusion protein with four binding sites, two of which bind to tumor cell surface antigens and the other two to the immune cells. TandAbs do not carry Fc domains, are smaller than whole IgGs or IgG-derived BsAbs but larger than BiTEs. Therefore, they have a shorter serum half-life than IgGs but remain longer in the circulation compared with BiTEs. The BsAb can be used in pretargeting system of PET, radioimaging or radiotherapy. It can mediate targeting of radioactivity to tumor cells. It was designed for the treatment of solid tumors.      

Specifications
Targets
FN1 & HSG
Type
TandAb
Expression Host
CHO
Species Reactivity
Human
Target 1
FN1
Target 2
HSG
Clone
m679
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
solid tumors
Targets
Target 1
FN1
Gene ID
2335
UniProt ID
P02751
Alternative Names
FN1; fibronectin 1; FN; CIG; FNZ; MSF; ED-B; FINC
Target 2
HSG
Alternative Names
histaminyl-succinyl-glycine; HSG

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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