Products

Anti-TROP-2 × Anti-HSG Bispecific Antibody (TAND-L061)

Recombinant Anti-TROP-2 × Anti-HSG Bispecific Antibody (TandAb) is a bispecific fusion protein with four binding sites, two of which bind to antigens of one kind of cells and the other two to the other kind of cells. TandAbs do not carry Fc domains, are smaller than whole IgGs or IgG-derived bsAbs, but larger than BiTEs. Therefore, they have a shorter serum half-life than IgGs but remain longer in the circulation compared with BiTEs. The BsAb can be used in pretargeting system of PET, radioimaging or radiotherapy. It can mediate targeting of radioactivity to tumor cells.It was designed for the imaging and treatment of prostate cancer.      

Specifications
Targets
TROP-2 & HSG
Type
TandAb
Expression Host
CHO
Species Reactivity
Human
Target 1
TROP-2
Host
Human
Target 2
HSG
Host
Human
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Pretargeting system for radioimaging and radiotherapy
Related Disease
prostate cancer
Targets
Target 1
TROP-2
Gene ID
4070
UniProt ID
P09758
Alternative Names
TACSTD2; tumor-associated calcium signal transducer 2; EGP1; GP50; M1S1; EGP-1; TROP2; GA7331
Target 2
HSG
Alternative Names
histaminyl-succinyl-glycine; HSG

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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