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APC-HLA-A2/Human IRS2 (RVASPTSGV) MHC Tetramer (CAT#: MHC-LC1446)

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of IRS2-derived peptide of RVASPTSGV covering 1097-1105 and HLA-A2 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.


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Specific Inquiry
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  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Figure 1 IF staining of human cell line HeLa
Figure 1 IF staining of human cell line HeLa
(Immunofluorescent staining of human cell line HeLa shows localization to cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54664/881_A4_1_selected.jpg
Normal Tissue
Figure 2 Colon
Figure 2 Colon
(Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16944/36406_A_9_3.jpg
Figure 3 Kidney
Figure 3 Kidney
(Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16944/36406_A_8_5.jpg
Figure 4 Testis
Figure 4 Testis
(Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16944/36406_A_6_6.jpg
Figure 5 Skeletal muscle
Figure 5 Skeletal muscle
(Myocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16944/36406_B_2_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (hTERT-HME1, LHCN-M2, SH-SY5Y, THP-1)
Figure 6 RNA cell line category: Cell line enhanced (hTERT-HME1, LHCN-M2, SH-SY5Y, THP-1)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000185950-IRS2

Specifications

  • Allele
  • HLA-A2
  • Class
  • Class I
  • Antigen
  • IRS2
  • Antigen Species
  • Human
  • Peptide
  • RVASPTSGV
  • Range
  • 1097-1105
  • Conjugate
  • APC
  • Application
  • FCM

Target

  • Antigen Introduction
  • This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.
  • Alternative Names
  • IRS2; insulin receptor substrate 2; IRS-2

Related Resources

  • Related Signaling Pathways

Downloads

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See other products for "IRS2"

Recombinant Antibody

CAT Product Name Application Type
MOB-3735z Mouse Anti-IRS2 Recombinant Antibody (clone 19B2) WB, IP, IF, ELISA Mouse IgG1, κ

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-LC1445 PE-HLA-A2/Human IRS2 (RVASPTSGV) MHC Tetramer FCM
MHC-LC1447 BV421-HLA-A2/Human IRS2 (RVASPTSGV) MHC Tetramer FCM
MHC-YF503 A*02:01/Human Insulin receptor substrate-2 (RVA(PHOSPHO-S)PTSGV) MHC Pentamer FCM
MHC-YF504 A*02:01/Human IRS-2 (RVASPTSGV) MHC Pentamer FCM

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1862 Hi-Affi™ Recombinant Rabbit Anti-IRS2 Monoclonal Antibody (DS1862AB) ICC/IF, IHC-P, IP, WB IgG

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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