Products

Anti-38C13 Id Immunocytokine, IgG-IL2 (ACFP-SH154)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-38C13 Id IgG to IL2. It was expressed in CHO and purified with affinity chromatography. This antibody-cytokine fusion protein retains antigen-binding and cytokine activity and was able to target 38C13 subcutaneous tumors in miceas well as the biological activity of IL2. Importantly, anti-Id IgG3-(IL-2) showed enhanced antitumor activity compared with the combination of antibody and IL-2 administered together. This immunocytokine was designed for treating B cell lymphoma.      

Specifications
Target
38C13 Id
Molecule Class
IgG3-IL2
Species Reactivity
Human
Host
human
Expression Host
CHO
Related Disease
B cell lymphoma
Cytokines 1
IL2
Cytokines 1 Description
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
38C13 Id; 38C13 idiotype

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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