Anti-AGS-16 (AGS-16M7.8)-Mc-MMAF ADC (AGS-16M8F) (CAT#: ADC-L003)
This ADC product is composed of an anti-AGS-16 antibody (clone AGS-16M7.8) conjuagated via a Mc linker to MMAF (AGS-16M7.8-mc-MMAF). It has demonstrated a response in liver cancer, renal cancer treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.
Specific Inquiry
Specifications
- Antibody Overview
- Fully human IgG2k monoclonal antibody that binds to AGS-16
- Clone
- AGS-16M7.8
- Antibody Conjugation
- Human
- Linker
- Mc (maleimidocaproyl)
- Linker Class/Description
- Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
- Drug
- MMAF (Monomethyl auristatin F)
- Drug Class/Description
- Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- AGS-16M18 is a fully human monoclonal antibody directed to a novel target AGS-16 for the treatment of kidney and liver cancers.
- Alternative Names
- AGS-16
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Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-027CL | Human Anti-AGS-16 Recombinant Antibody (TAB-027CL) | ELISA | Human IgG2, κ |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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