Products

Anti-CD70 Immunocytokine, IgG (c1F6)-IFNγ (ACFP-SH160)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-CD70 IgG to IFNγ. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the CD70 as well as the biological activity of IFNγ. The immunocytokine displays high levels of species-specific IFN-γ activity and selective binding to CD70 on human RCC cells. This immunocytokine was designed for treating Metastatic renal cell carcinoma.      

Specifications
Target
CD70
Molecule Class
L Kappa; IgG1-IFNγ
Species Reactivity
Human
Host
Chimeric (Human-Mouse)
Expression Host
CHO
Clone
c1F6
Related Disease
Metastatic renal cell carcinoma
Cytokines 1
IFNγ
Cytokines 1 Description
Interferon gamma (IFNγ) is a dimerized soluble cytokine that is the only member of the type II class ofinterferons. The existence of this interferon, which early in its history was known as immune interferon, was described by E. F. Wheelock as a product of human leukocytes stimulated with phytohemagglutinin, and by others as a product of antigen-stimulated lymphocytes or tuberculin-sensitized mouse peritoneal lymphocytes challenged with PPD; the resulting supernatants were shown to inhibit growth of vesicular stomatitis virus. Those reports also contained the basic observation underlying the now widely employed interferon gamma release assay used to test for tuberculosis. In humans, the IFNγ protein is encoded by the IFNG gene.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
CD70; CD70 molecule; CD27L; CD27LG; TNFSF7; CD70 antigen; CD27-L; CD27 ligand
Entrez Gene ID
970
UniProt ID
P32970

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
Send Inquiry Now!
Name:
* Phone:
* E-mail Address:
* Service & Products Interested:
Project Description:
* Verification Code:
Please input "biolabs"(case insensitive) as verification code.
Contact Us to Order
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

45-1 Ramsey Road, Shirley, NY 11967, USA     Tel: 1-631-871-5806    Fax: 1-631-207-8356    Email:
Terms of Service-Privacy Policy     © 2007 - 2017 Creative-Biolabs All Rights Reserved