Products

Anti-FAP Immunocytokine, IgG (4G8)-IL10 (ACFP-SH012)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the IL10 (wild type human IL10 cytokine sequence) to C-terminus of Anti-FAP IgG heavy chain (with engineered Fc-region to avoid effector functions). It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the FAP as well as the biological activity of IL10. This immunocytokine was designed for treating inflammatory diseases.      

Specifications
Target
FAP
Molecule Class
IgG1-IL10
Species Reactivity
Human
Host
Human
Expression Host
CHO
Clone
4G8
Related Disease
inflammatory diseases
Cytokines 1
IL10
Cytokines 1 Description
Viral interleukin-10 has now been termed viral interleukin 10 (vlL-10) to reflect its protein sequence homology to "cellular" IL10 (cIL10, either murine or human IL10). It is now widely accepted that vlL-10 shares many functions with clL-10, principally, the ability to enhance survival of newly infected B cells and to diminish the production of IFN-β and IL-2 during ongoing immune reactions.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
FAP; fibroblast activation protein; alpha; FAPA; SIMP; DPPIV; prolyl endopeptidase FAP; seprase
Entrez Gene ID
2191
UniProt ID
Q12884

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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