Afuco™ Anti-Human IGF1 ADCC Recombinant Antibody (BI 836845), ADCC Enhanced (CAT#: AFC-370CL)
Anti-IGF1 ADCC Enhanced Antibody (BI 836845) is an ADCC enhanced antibody produced by our Afuco™ platform. BI 836845 is a HumAb of the IgG1 isotype against the human insulin-like growth factors IGF-1 and IGF-2, which are up-regulated in many tumors. BI 836845 is well tolerated in patients with advanced solid tumours. An RBD of 1000 mg weekly was identified. An expansion phase is ongoing and recruiting patients with Ewing sarcoma or all tumor types with biopsiable disease.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Normal Tissue
RNA Expression
Figure 1 IHC staining of human colon
(Immunohistochemical staining of human colon shows plasma positivity.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/ihc_selected.jpg
(Immunohistochemical staining of human colon shows plasma positivity.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/ihc_selected.jpg
Figure 2 Colon
(Endothelial cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/110992_A_7_3.jpg
(Endothelial cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/110992_A_7_3.jpg
Figure 3 Rectum
(Glandular cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/110992_A_4_3.jpg
(Glandular cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/110992_A_4_3.jpg
Figure 4 Liver
(Hepatocytes Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/110992_A_9_4.jpg
(Hepatocytes Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/110992_A_9_4.jpg
Figure 5 Testis
(Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/110992_A_4_6.jpg
(Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/110992_A_4_6.jpg
Figure 6 RNA cell line category: Cell line enhanced (ASC diff, HDLM-2, K-562, Karpas-707, U-266/70)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000017427-IGF1/
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000017427-IGF1/
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by analysis by SDS-PAGE
- Storage
- Short Term Storage: 4°C
Long Term Storage: -20°C
Target
- Alternative Names
- IGF1; insulin-like growth factor 1 (somatomedin C); IGFI; IGF-I; IGF1A; insulin-like growth factor I; MGF; IGF-IA; IGF-IB; somatomedin-C; mechano growth factor; insulin-like growth factor IA; insulin-like growth factor IB
- Gene ID
- 3479
- UniProt ID
- P05019
Related Resources
Insulin Signaling Pathway
Endocrine Resistance
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-385CL | Anti-Human IGF1 Recombinant Antibody (TAB-385CL) | WB, FuncS | Antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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