Anti-SCL44A4-mc-vc-MMAE ADC (AGS-5ME) (CAT#: ADC-L007)
This ADC product is composed of an anti-SCL44A4 antibody conjuagated via a Mc-vc linker to MMAE (anti-SCL44A4 antibody-mc-vc-MMAE). It has demonstrated a response in pancreatic cancer treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.
Specific Inquiry
Specifications
- Antibody Overview
- Fully human IgG2k monoclonal antibody that binds to AGS-5
- Antibody Conjugation
- Human
- Linker
- mc-vc (maleimidocaproyl-valine-alanine)
- Linker Class/Description
- Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Drug
- MMAE (Monomethyl auristatin E)
- Drug Class/Description
- Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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