Anti-cKit-maitansine ADC (LOP628) (CAT#: ADC-L039)
This ADC product is composed of an anti-cKit antibody conjuagated to maitansine (anti-cKit antibody-maitansine). It has demonstrated a response in Inflammatory Diseases treatment by a MOA (Mechanism of Action) of .
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HEK 293
(Immunofluorescent staining of human cell line HEK 293 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73252/1469_D7_6_selected.jpg
(Immunofluorescent staining of human cell line HEK 293 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/73252/1469_D7_6_selected.jpg
Figure 2 High expression in breast
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4471/ihc_selected.jpg
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4471/ihc_selected.jpg
Figure 3 High expression in lung.
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3288/8181_A_1_4_val_selected.jpg
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3288/8181_A_1_4_val_selected.jpg
Figure 4 Skin
(Melanocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3288/8181_B_8_1.jpg
(Melanocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3288/8181_B_8_1.jpg
Figure 5 RNA cell line category: Group enriched (HEL, HMC-1)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000157404-KIT
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000157404-KIT
Specifications
- Antibody Overview
- Humanized IgG1/κ antibody
- Antibody Conjugation
- Humanized
- Linker
- non-cleavable linker
- Drug
- maitansine
- Drug Class/Description
- Maitansine (INN), or maytansine (USAN), is a cytotoxic agent. It inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site.
Target
- Introduction
- This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.
- Alternative Names
- PBT; SCFR; C-Kit; CD117
- Gene ID
- 3815
- UniProt ID
- P10721
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "KIT"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1436z | Mouse Anti-KIT Recombinant Antibody (clone 21G5) | ELISA, IHC, WB | Mouse IgG |
| PABL-642 | Mouse Anti-KIT Recombinant Antibody (clone 79D) | WB, FuncS | Mouse IgG |
| TAB-468LC | Human Anti-KIT Recombinant Antibody (TAB-468LC) | ELISA | Human IgG1, κ |
| MOB-0966MZ | Recombinant Mouse Anti-Human KIT Antibody (clone C-L26) | ELISA | Mouse antibody |
| FAMAB-0024-CN | Mouse Anti-KIT Recombinant Antibody (clone Kit2C75) | FC | Mouse IgG |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-470CL | Human Anti-KIT Recombinant Antibody (TAB-470CL) | ELISA, WB | Human IgG |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-450CL | Afuco™ Anti-KIT Recombinant Antibody (AFC-450CL), ADCC Enhanced | ELISA, WB | Humanized IgG1 |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-625 | Human Anti-KIT Recombinant Antibody (clone 19); scFv Fragment | ELISA | Human scFv |
| PSBL-637 | Mouse Anti-KIT Recombinant Antibody (clone 79D); scFv Fragment | WB, FuncS | Mouse scFv |
| HPAB-0019-FY-S(P) | Human Anti-KIT Recombinant Antibody; scFv Fragment (HPAB-0019-FY-S(P)) | FC | Humanized scFv |
| HPAB-3398LY-S(P) | Human Anti-KIT Recombinant Antibody (clone 37M); scfv Fragment | ELISA, FC, WB | Human scfv |
| HPAB-1950-FY-S(P) | Human Anti-KIT Recombinant Antibody; scFv Fragment (HPAB-1950-FY-S(P)) | Block, ELISA, FC, IF | Humanized scFv |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-467LC | Anti-Human KIT Recombinant Antibody (SR1) | WB | |
| TAB-467LC-S(P) | Anti-Human KIT Recombinant Antibody scFv Fragment (SR1) | WB | |
| TAB-467LC-F(E) | Anti-Human KIT Recombinant Antibody Fab Fragment (SR1) | WB |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-465LC-S(P) | Human Anti-KIT Recombinant Antibody; scFv Fragment (TAB-465LC-S(P)) | FC, WB, SPR, ELISA | Human scFv |
| TAB-466LC-S(P) | Human Anti-KIT Recombinant Antibody; scFv Fragment (TAB-466LC-S(P)) | FC, WB, SPR, ELISA | Human scFv |
| TAB-468LC-S(P) | Human Anti-KIT Recombinant Antibody; scFv Fragment (TAB-468LC-S(P)) | FC, WB, ELISA | Human scFv |
| TAB-465LC-F(E) | Human Anti-KIT Recombinant Antibody; Fab Fragment (TAB-465LC-F(E)) | FC, WB, SPR, ELISA | Human Fab |
| TAB-466LC-F(E) | Human Anti-KIT Recombinant Antibody; Fab Fragment (TAB-466LC-F(E)) | FC, WB, SPR, ELISA | Human Fab |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0316MZ | Chicken Anti-KIT Polyclonal IgY | WB | Chicken antibody |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1629CQ | Recombinant Mouse Anti-KIT Antibody (A3C6E2) | FC, BL | IgG1, κ |
| NEUT-1633CQ | Recombinant Rat Anti-Kit Antibody (ACK2) | FC, BL, Depletion | IgG2b, κ |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1630CQ | Recombinant Mouse Anti-KIT Antibody (CBL788) | WB, FC, CyTOF, ELISA(Cap), Neut | IgG1 |
| NEUT-1631CQ | Recombinant Mouse Anti-KIT Antibody (14G5) | Neut, WB | IgG1 |
| NEUT-1632CQ | Recombinant Mouse Anti-KIT Antibody (12A8) | WB, IP, FC, Neut | IgG1 |
| NEUT-1634CQ | Recombinant Mouse Anti-KIT Antibody (CBL158) | Neut, WB | IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1948 | Hi-Affi™ Recombinant Rabbit Anti-KIT Monoclonal Antibody (DS1948AB) | IHC-P, IHC-Fr | IgG |
| MOR-4551 | Hi-Affi™ Recombinant Rabbit Anti-KIT Monoclonal Antibody (TH61DS) | WB, IF, ICC | IgG |
| MOR-4552 | Hi-Affi™ Recombinant Rabbit Anti-KIT Monoclonal Antibody (TH62DS) | WB, IF, ICC, FC | IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0024-CN-F(E) | Mouse Anti-KIT Recombinant Antibody (clone Kit2C75); Fab Fragment | FC | Mouse Fab |
| HPAB-1570-FY-S(P) | Human Anti-KIT Recombinant Antibody; scFv Fragment (HPAB-1570-FY-S(P)) | WB, ELISA | Human scFv |
| HPAB-1571-FY-S(P) | Human Anti-KIT Recombinant Antibody; scFv Fragment (HPAB-1571-FY-S(P)) | WB, ELISA | Human scFv |
| HPAB-1572-FY-S(P) | Human Anti-KIT Recombinant Antibody; scFv Fragment (HPAB-1572-FY-S(P)) | WB, ELISA | Human scFv |
| HPAB-1952-FY-F(E) | Mouse Anti-KIT Recombinant Antibody; Fab Fragment (HPAB-1952-FY-F(E)) | Block, ELISA, FC, IF | Mouse Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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