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BV421-B*44:02/Human HLA-DPA1 (EEAGRAFSF) MHC Tetramer (CAT#: MHC-LC1516)

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of HLA-DPA1-derived peptide of EEAGRAFSF covering 77-85 and B*44:02 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.


See more MHC Tetramer products for HLA-DPA1
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  • Gene Expression
  • Datasheet
  • MSDS
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Subcellular Location
Figure 1 IF staining of human cell line HEK 293
Figure 1 IF staining of human cell line HEK 293
(Immunofluorescent staining of human cell line HEK 293 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/17967/1639_G1_1_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Figure 2 Cerebral cortex
(Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/17967/41094_B_7_5.jpg
Figure 3 Testis
Figure 3 Testis
(Spermatogonia cells Staining: Low Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/17967/41094_A_5_6.jpg
Figure 4 Lymph node
Figure 4 Lymph node
(Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/17967/41094_A_8_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (Daudi, HDLM-2, REH, U-698)
Figure 5 RNA cell line category: Cell line enhanced (Daudi, HDLM-2, REH, U-698)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000231389-HLA-DPA1

Specifications

  • Allele
  • B*44:02
  • Class
  • Class I
  • Antigen
  • HLA-DPA*02:01
  • Antigen Species
  • Human
  • Peptide
  • EEAGRAFSF
  • Range
  • 77-85
  • Conjugate
  • BV421
  • Application
  • FCM

Target

  • Antigen Introduction
  • HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
  • Alternative Names
  • HLA-DPA1; Major histocompatibility complex, class II, DP alpha 1; PLT1; HLADP; HLASB; DP(W3); DP(W4); HLA-DP1A

Downloads

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See other products for "HLA-DPA1"

Recombinant Antibody

CAT Product Name Application Type
MOB-1980z Mouse Anti-HLA-DPA1 Recombinant Antibody (clone 3F10) ELISA, WB Mouse IgG2a, κ
MOB-0049MZ Recombinant Mouse Anti-Human HLA, Class II antigen-DR+DP Antibody (clone A237-14241) FC, IP Mouse antibody
VS3-CJ760 Mouse Anti-HLA-DPA1 Recombinant Antibody (clone B7/21) IF, FC Mouse IgG1, κ
VS3-FY678 Recombinant Mouse Anti-HLA-DPA1 Antibody (clone 2B1A10) ELISA, WB, IHC, FC Mouse IgG2a
VS3-FY679 Recombinant Mouse Anti-HLA-DPA1 Antibody (clone 6C3D8) ELISA, IHC, FC Mouse IgG2b

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-LC1514 PE-B*44:02/Human HLA-DPA1 (EEAGRAFSF) MHC Tetramer FCM
MHC-LC1517 PE-B*44:02/Human HLA-DPA1 (EEFGAAFSF) MHC Tetramer FCM
MHC-LC1520 PE-B*44:02/Human HLA-DPA1 (EEFGRAASF) MHC Tetramer FCM
MHC-LC1523 PE-B*44:02/Human HLA-DPA1 (EEAGAAFSF) MHC Tetramer FCM
MHC-LC1526 PE-B*44:02/Human HLA-DPA1 (EEFGAAASF) MHC Tetramer FCM

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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