Anti-fat R2 (clone Bat0606)-SMCC-MDC ADC (CAT#: ADC-159CL)
This ADC product is composed of an anti-fat R2 antibody (clone Bat0606) conjugated via SMCC linker to MDC(Bat0606-MCC-MDC). It has demonstrated a response in gastric cancer treatment.
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Specifications
- Antibody Overview
- Anti-fat R2 Antibody Bat0606
- Clone
- Bat0606
- Linker
- SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Linker Class/Description
- Class: Noncleavable linkers
Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
- Drug
- MDC (maytansinol)
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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