Recombinant Anti-FcγRI × Anti-HER2 Bispecific Antibody (Fab2) (CAT#: FAB-L017)
Recombinant Anti-FcγRI × Anti-HER2 Bispecific Antibody (Fab2) is composed of the Fab of the anti-FcγRI monoclonal antibody and Fab of an antibody specific for HER2. A linker is added between the two Fab. The bispecific antibody is somewhat smaller than a whole IgG and therefore it clears from the blood naturally at a faster rate. This BsAb can retarget of immune cells to tumor cells. It was designed for the treatment of breast cancer.
Specific Inquiry
Specifications
- Target
- FcγRI & HER2
- Type
- Fab2
- Species Reactivity
- Human
- Target 1
- FcγRI
- Host Species 1
- Human
- Target 2
- HER2
- Host Species 2
- Human
- Application
- FuncS, Promising therapeutic agent
- Related Disease
- Breast cancer
Target
- Target 1
- FcγRI
- Gene ID
- 2209
- UniProt ID
- P12314
- Alternative Names
- CD64; FCRI; CD64A; IGFR1
- Target 2
- HER2
- Gene ID
- 2064
- UniProt ID
- P04626
- Alternative Names
- ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; human epidermal growth factor receptor 2; neuro/glioblastoma derived oncogene homolog; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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