Products

Anti-HER2 × Anti-MET Bispecific Antibody (TAND-L007)

Recombinant Anti-HER2 × Anti-c-Met Bispecific Antibody (TandAb) is a bispecific fusion protein with four binding sites, two of which bind to antigens of one kind of cells and the other two to the other kind of cells. TandAbs do not carry Fc domains. So they are smaller than whole IgGs or IgG-derived BsAbs, but larger than BiTEs. Therefore, they have a shorter serum half-life than IgGs but remain longer in the circulation compared with BiTEs. This BsAb can simultaneously block two receptors. It was designed for the treatment of numerous cancers, including prostate tumor, bladder tumor, and breast tumor,kidney cancer, liver cancer, stomach cancer, breast cancer and brain cancer.      

Specifications
Targets
HER2 & MET
Type
TandAb
Expression Host
CHO
Species Reactivity
Human
Target 1
HER2
Host
Human
Clone
SER4
Target 2
MET
Host
Human
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
Numerous cancers, including prostate tumors, bladder tumors, and breast tumors,kidney cancers, liver cancers, stomach cancers, breast cancers, brain cancers
Targets
Target 1
HER2
Gene ID
2064
UniProt ID
P04626
Alternative Names
ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2
Target 2
MET
Gene ID
4233
UniProt ID
P08581
Alternative Names
MET; MET proto-oncogene, receptor tyrosine kinase; HGFR; AUTS9; RCCP2; c-Met; hepatocyte growth factor receptor; SF receptor; HGF receptor; HGF/SF receptor; proto-oncogene c-Met; scatter factor receptor; tyrosine-protein kinase Met; met proto-oncogene tyrosine kinase

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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