Follitropin beta is a human follicle stimulating hormone (FSH) preparation of recombinant DNA origin, which consists of two non-covalently linked, non-identical glycoproteins designated as the alpha- and beta- subunits. The alpha- and beta- subunits have 92 and 111 amino acids. The alpha subunit is glycosylated at Asn 51 and Asn 78 while the beta subunit is glycosylated at Asn 7 and Asn 24. Follitropin beta is produced in genetically engineered Chinese hamster cell lines (CHO). The nomenclature "beta" differentiates it from another recombinant human FSH product that was marketed earlier as follitropin alpha. Follitropin is important in the development of follicles produced by the ovaries. Given by subcutaneous injection, it is used in combination with human chorionic gonadotropin (hCG) to assist in ovulation and fertility. Follitropin may also be used to cause the ovary to produce several follicles, which can then be harvested for use in gamete intrafallopian transfer (GIFT) or in vitro fertilization (IVF). Numerous physio-chemical tests and bioassays indicate that follitropin beta and follitropin alpha are indistinguishable. However, a more recent study showed there is may be a slight clinical difference, with the alpha form tending towards a higher pregnancy rate and the beta form tending towards a lower pregnancy rate, but with significantly higher estradiol (E2) levels. Structural analysis shows that the amino acid sequence of follitropin beta is identical to that of natural human follicle stimulating hormone (FSH). Further, the ogliosaccharide side chains are very similar, but not completely identical to that of natural FSH. However, these small differences do not affect the bioactivity compared to natural FSH.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-372-F(E) | Recombinant Anti-human FSHB Antibody Fab Fragment | IP, FuncS | Fab |
MHH-372-F(E) | Recombinant Human Anti-human FSHB Antibody Fab Fragment | ELISA, WB, FC, FuncS | Fab |
PFBC-135 | Mouse Anti-FSHB Recombinant Antibody (clone 46.3H6.B7); Fab Fragment | ELISA | Mouse Fab |
HPAB-0363-YJ-F(E) | Human Anti-FSHB Recombinant Antibody (clone B3); Fab Fragment | ELISA, WB, FuncS | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-372-S(P) | Recombinant Anti-human FSHB Antibody scFv Fragment | WB, IHC, FuncS | scFv |
MHH-372-S(P) | Recombinant Human Anti-human FSHB Antibody scFv Fragment | WB, FC, FuncS | scFv |
PSBC-135 | Mouse Anti-FSHB Recombinant Antibody (clone 46.3H6.B7); scFv Fragment | ELISA | Mouse scFv |
HPAB-0363-YJ-S(P) | Human Anti-FSHB Recombinant Antibody (clone B3); scFv Fragment | ELISA, WB, FuncS | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MHH-372 | Recombinant Human Anti-human FSHB Antibody | ELISA, FuncS | IgG |
HPAB-0363-YJ | Human Anti-FSHB Recombinant Antibody (clone B3) | ELISA, WB, FuncS | Human IgG |
ZG-0038C | Mouse Anti-FSHB Recombinant Antibody (clone ABT-FSH) | IHC-P, IF | Mouse IgG |
ZG-0039C | Mouse Anti-FSHB Recombinant Antibody (clone PT0555) | IHC-P, IF | Mouse IgG |
VS3-FY565 | Recombinant Mouse Anti-FSHB Antibody (clone 2H7B1) | ELISA, IHC, FC | Mouse IgG2a |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1355 | Hi-Affi™ Rabbit Anti-FSHB Recombinant Antibody (clone DS1355AB) | WB, IP | Rabbit IgG |
There are currently no Customer reviews or questions for TP-034CL. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.