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Interferon alfacon-1 (TP-037CL)

Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional amino acid changes were made to facilitate the molecular construction, and a corresponding synthetic DNA sequence was constructed using chemical synthesis methodology. Interferon alfacon-1 differs from interferon alfa-2b at 20/166 amino acids (88% homology), and comparison with interferon-beta shows identity at over 30% of the amino acid positions. Interferon alfacon-1 is produced in Escherichia coli (E. coli) cells that have been genetically altered by insertion of a synthetically constructed sequence that codes for Interferon alfacon-1. Prior to final purification, Interferon alfacon-1 is allowed to oxidize to its native state, and its final purity is achieved by sequential passage over a series of chromatography columns. This protein has a molecular weight of 19,434 daltons.      

Specifications
Classify
Protein therapeutics augmenting an existing pathway: Immunoregulation
Therapeutic
Type I alpha-interferon, interferon alfacon 1, consensus interferon
Trade Name
Infergen
Function
Mechanism unknown; immunoregulator
Examples of Clinical Use
Chronic hepatitis c infection
References
Synonyms
CIFN, consensus interferon, IFN Alfacon-1, Interferon Consensus, Methionyl, methionyl interferon consensus, methionyl-interferon-consensus, rCon-IFN, Recombinant Consensus Interferon, Recombinant methionyl human consensus interferon
Genbank
J00207

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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