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Kunitz domains anti-αvβ3 Integrin (SKD-L094)

The Kunitz domain that bound αvβ3 integrin was isolated from the library using phage display techonology. Kunitz domains are stable as standalone peptides, able to recognise specific protein structures, and also work as competitive protease inhibitors in their free form. After affinity maturation, Kunitz domains variants were identified having affinities (KD=0.3 nM) for αvβ3 integrin as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.      

Specifications
Scaffold Name
Kunitz domains
Origin
Knottin protein
Variable Regions
9-13 amino acids
Target
αvβ3 integrin
Species Reactivity
Human
Expression Host
E. coli
Affinity Constant
0.3 nM
Applications
ELISA; IHC; Microscopy; FC; WB; FuncS
Target
Alternative Names
knottin protein; Kunitz domains; αvβ3 Integrin; αVβ3; integrin

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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