Products

Mecasermin (TP-010CL)

Mecasermin contains recombinant-DNA-engineered human insulin-like growth factor-1 (rhIGF-1). IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges and a molecular weight of 7649 daltons. The amino acid sequence of the product is identical to that of endogenous human IGF-1. The rhIGF-1 protein is synthesized in bacteria (E. coli) that have been modified by the addition of the gene for human IGF-1.      

Specifications
Classify
Protein therapeutics replacing a protein that is deficient or abnormal: Endocrine disorders (hormone deficiencies)
Therapeutic
Mecasermin rinfabate
Trade Name
IPlex
Function
Similar to mecasermin; iGF1 bound to iGF binding protein 3 (iGFBP3) is thought to keep the hormone inactive until it reaches its target tissues, thereby decreasing hypoglycaemia-like side effects
Examples of Clinical Use
Growth failure in children with GH gene deletion or severe primary iGF1 deficiency
References
Synonyms
IGF-1, IGF1, Insulin-like growth factor 1, Mecasermin recombinant, Mecasermin rinfabate, Mecasermin rinfabate recombinant, Mechano growth factor, Somatomedin-C

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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