Obinutuzumab (CAT#: Gly-003CL)

Obinutuzumab is a humanized monoclonal antibody used as a combination treatment with chlorambucil to treat patients with untreated chronic lymphocytic leukemia. It was approved by the FDA in November 2013 and is marketed under the brand name Gazyva. There is a black box warning of fatal Hepatitis B Virus (HBV) reactivation and fatal Progressive Multifocal Leukoencephalopathy (PML).


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  • Gene Expression
  • Datasheet
  • MSDS
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Subcellular Location and Protein Expression
Normal Tissue
RNA Expression

Specifications

  • Type
  • Biotech
  • Protein chemical formula
  • C6512H10060N1712O2020S44
  • Protein average weight
  • 146100.0 Da
  • CAS number
  • 949142-50-1
  • Class
  • Carboxylic Acids and Derivatives
  • Mechanism of action
  • In contrast to rituximab, which is a classic type I CD20 antibody, obinutuzumab binds to type II CD20 antibodies. This allows obinutuzumab to have a much higher induction of antibody-dependant cytotoxicity and a higher direct cytotoxic effect than the classic CD20 antibodies.

References

  • Synonyms
  • Afutuzumab

Downloads

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See other products for "MS4A1"

Recombinant Antibody

CAT Product Name Application Type
PABW-019 Human Anti-MS4A1 Recombinant Antibody (clone C2H7) WB, IF, FuncS Chimeric (mouse/human) IgG
PABL-422 Human Anti-MS4A1 Recombinant Antibody (clone 2F2) WB, ELISA, FuncS Human IgG1,κ
PABL-423 Mouse Anti-MS4A1 Recombinant Antibody (clone GA101) FC, Activ, Agonist, IF, WB, Cyt, FuncS Mouse IgG
HPAB-0018-FY Human Anti-MS4A1 Recombinant Antibody (HPAB-0018-FY) FC Humanized IgG1
HPAB-0021-FY Human Anti-MS4A1 Recombinant Antibody (clone hu3D9) FC Humanized IgG

Hyper-galactosylated

High-mannose Glycoform

CAT Product Name Application Type
Gly-155LC-1 Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/High-mannose glycosylated) ELISA Humanized antibody

Deglycosylated Antibody (Non-glycosylated IgGs)

CAT Product Name Application Type
Gly-171LC Recombinant Anti-Human MS4A1 Antibody (Non-glycosylated) ELISA Chimeric antibody (mouse/human)

Neutralizing Antibody

CAT Product Name Application Type
NEUT-1751CQ Mouse Anti-MS4A1 Recombinant Antibody (clone CBLS-211) Neut, FuncS Mouse IgG1, κ

Rabbit Monoclonal Antibody

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-772 Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ocrelizumab), ADCC Enhanced ELISA, IP, FC, FuncS, Neut, IF ADCC enhanced antibody
AFC-TAB-016 Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Rituximab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody
AFC-TAB-028 Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ofatumumab), ADCC Enhanced FC, IP, ELISA, Neut, FuncS, IF ADCC enhanced antibody
AFC-TAB-207 Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ublituximab), ADCC Enhanced ELISA, IP, FC, FuncS, Neut, IF ADCC enhanced antibody
AFC-TAB-771 Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ocaratuzumab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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