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PDZ domain anti-EphB4 (SPD-L160)

The PDZ domain that bound ErbB4 was isolated from the library using Yeast Two-hybrid techonology. PDZ domains are modular protein-interaction domains that are specialized for binding to short peptide motifs at the extreme carboxy (C) termini of other proteins, athough they can also have other modes of interaction. After affinity maturation, PDZ domain variants were identified having affinities for ErbB4 as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.      

Specifications
Scaffold Name
PDZ domain
Origin
PSD-95 protein
Core Structure
β-sheet
Target
ErbB4
Species Reactivity
Human
Expression Host
E. coli
Applications
ELISA; IHC; Microscopy; FC; WB; FuncS
Target
Alternative Names
PSD-95 protein; PDZ domain; HTK; MYK1; TYRO11
Entrez Gene ID
2050
UniProt ID
P54760

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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