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PE-A*69:01/Human KPNA2 (ELPIVTPAL) MHC Tetramer (CAT#: MHC-LC4438)

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human KPNA2 of peptide ELPIVTPAL covering 306-314 and A*69:01 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.


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Specific Inquiry
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  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Figure 1 IF staining of human cell line MCF7
Figure 1 IF staining of human cell line MCF7
(Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/41270/if_selected.jpg
Figure 2 IF staining of human cell line U-2 OS
Figure 2 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15460/945_C8_3_selected.jpg
Normal Tissue
Figure 3 Testis
Figure 3 Testis
(Elongated or late spermatids Staining: Low Intensity: Moderate Quantity: <25% Pachytene spermatocytes Staining: High Intensity: Strong Quantity:>75% Preleptotene spermatocytes Staining: High Intensity: Strong Quantity:>75% Round or early spermatids Staining: High Intensity: Strong Quantity:>75% Spermatogonia cells Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15460/34903_A_4_6.jpg
Figure 4 Lymph node
Figure 4 Lymph node
(Germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: nuclear Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15460/34903_A_8_8.jpg
Figure 5 Cerebral cortex
Figure 5 Cerebral cortex
(Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15460/34903_B_7_5.jpg
Figure 6 Liver
Figure 6 Liver
(Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15460/34903_A_8_4.jpg
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Figure 7 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000182481-KPNA2

Specifications

  • Allele
  • A*69:01
  • Class
  • Class I
  • Antigen
  • KPNA2
  • Antigen Species
  • Human
  • Peptide
  • ELPIVTPAL
  • Range
  • 306-314
  • Conjugate
  • PE
  • Application
  • FCM

Target

  • Antigen Introduction
  • The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
  • Alternative Names
  • KPNA2; Importin subunit alpha-2; QIP2; RCH1; IPOA1; SRP1alpha; SRP1-alpha

Downloads

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See other products for "KPNA2"

Recombinant Antibody

CAT Product Name Application Type
MOB-3100z Mouse Anti-KPNA2 Recombinant Antibody (clone 4B8) WB, ELISA, FC, ICC, IF, IHC, ICC, IF Mouse IgG1
MRO-0906-CN Recombinant Rabbit Anti-KPNA2 Monoclonal Antibody (JM90-33) WB, FC Rabbit IgG
VS1-YJ116 Rat Anti-KPNA2 Recombinant Antibody (clone 2G7) WB Rat IgG2a

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0276MZ Chicken Anti-Importin α2 subunit Polyclonal IgY WB Chicken antibody
BRD-1037MZ Chicken Anti-KPNA2 Polyclonal IgY WB Chicken antibody
BRD-1038MZ Chicken Anti-PPBP Polyclonal IgY WB Chicken antibody

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-LC1127 PE-HLA-Cw3/Human KPNA2 (GAVDPLLAL) MHC Tetramer FCM
MHC-LC1128 APC-HLA-Cw3/Human KPNA2 (GAVDPLLAL) MHC Tetramer FCM
MHC-LC1129 BV421-HLA-Cw3/Human KPNA2 (GAVDPLLAL) MHC Tetramer FCM
MHC-LC4437 PE-B*07:02/Human KPNA2 (ELPIVTPAL) MHC Tetramer FCM
MHC-LC4439 PE-B*40:01/Human KPNA2 (ELPIVTPAL) MHC Tetramer FCM

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1972 Hi-Affi™ Recombinant Rabbit Anti-KPNA2 Monoclonal Antibody (DS1972AB) WB, FC IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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