Anti-Nectin-4 (T-14)-vc-MMAE ADC (CAT#: ADC-148LCT)
This ADC product is composed of an anti-Nectin-4 antibody (clone T-14) conjuagated via a vc linker to MMAE (T-14-vc-MMAE). It has demonstrated a response in Multiple solid tumours to include breast, bladder, lung and pancreatic cancers treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.
Specific Inquiry
Specifications
- Antibody Overview
- Human IgG (Abgenix XenoMouse transgenic Mouse)
- Clone
- T-14
- Linker
- VC (valine-citrulline)
- Linker Class/Description
- Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Drug
- MMAE (Monomethyl auristatin E)
- Drug Class/Description
- Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and-heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011]
- Alternative Names
- PVRL4; poliovirus receptor-related 4; LNIR; PRR4; EDSS1; nectin-4; nectin-4; nectin 4; Ig superfamily receptor LNIR; poliovirus receptor-related protein 4;
- Gene ID
- 81607
- UniProt ID
- K4PZ75
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0805CT | Recombinant Mouse anti-Human PVRL4 Monoclonal antibody (EML1996) | WB |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-H25 | Afuco™ Anti-PVRL4 ADCC Recombinant Antibody (Enfortumab), ADCC Enhanced | ELISA, Neut, IF, IP, FC, FuncS | ADCC enhanced antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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