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Thyrotropin Alfa (TP-117CL)

Thyrotropin alfa is a recombinant form of thyroid stimulating hormone used in performing certain tests in patients who have or have had thyroid cancer. It is also used along with a radioactive agent to destroy remaining thyroid tissue in certain patients who have had their thyroid gland removed because of thyroid cancer. It is a heterodimeric glycoprotein comprised of two non-covalently linked subunits, an alpha subunit of 92 amino acid residues containing two N-linked glycosylation sites and a beta subunit of 112 residues containing one N-linked glycosylation site. The alpha subunit is nearly identical to that of human chorionic gonadotropin (hCG), luteinizing hormone (LH), and follicle-stimulating hormone (FSH). The alpha subunit is thought to be the effector region responsible for stimulation of adenylate cyclase (involved the generation of cAMP). The beta subunit (TSHB) is unique to TSH, and therefore determines its receptor specificity. The amino acid sequence of thyrotropin alfa is identical to that of human pituitary thyroid stimulating hormone.      

Specifications
Classify
Protein diagnostics: Hormones
Therapeutic
Thyroid stimulating hormone (TsH), thyrotropin
Trade Name
Thyrogen
Function
Stimulates thyroid epithelial cells or well- differentiated thyroid cancer tissue to take up iodine and produce and secrete thyroglobulin, triiodothyronine and thyroxine
Examples of Clinical Use
Adjunctive diagnostic for serum thyroglobulin testing in the follow-up of patients with well-differentiated thyroid cancer
References
Synonyms
rTSH, Thyroid stimulating hormone, Thyrotrophin-alfa, Thyrotrophin-alpha, Thyrotropin, Thyrotropin-a, Thyrotropin-alpha, Thytrophin, TSH
UniProt
P01225
Genbank
M16647

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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