This IgA specific binding protein (Z-domain of protein A) was investigated by an α-helix shuffling strategy. The primary scaffold protein was from a naive combinatorial library of the three-helix bundle Z domain derived from staphylococcal protein A. A hierarchical library was constructed through selective re-randomization of six amino acid positions in one of the two α-helices of the domain, making up the Taq DNA polymerase binding surface. After selections using monovalent phage display technology, second generation variants were identified having affinities (KD=0.5 μM) for IgA as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
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CAT | Product Name | Application | Type |
---|---|---|---|
NAB-2626-VHH | Recombinant Anti-human IgA VHH Single Domain Antibody | IP, FC, ChiP, Neut | Llama VHH |
NABG-115 | Llama Anti-human IgA VHH Single Domain Antibody [Biotin] | ELISA, WB, BLI, SPR |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1749 | Rabbit Anti-IgA Recombinant Antibody (clone DS1749AB) | WB, IP, ELISA, IHC-P, ICC, IF | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0837-FY | Human Anti-IgA Recombinant Antibody (HPAB-0837-FY) | ELISA | Human IgG |
HPAB-0709-WJ | Human Anti-IgA Recombinant Antibody (HPAB-0709-WJ) | WB, IHC, ELISA | Human IgG1 |
HPAB-0710-WJ | Human Anti-IgA Recombinant Antibody (HPAB-0710-WJ) | ELISA | Human IgG1 |
FAMAB-0209WJ | Mouse Anti-IgA Recombinant Antibody (clone IL-A71) | ELISA, WB | Mouse IgG |
VS3-WK537 | Rabbit Anti-IgA Recombinant Antibody (clone JM10-42) | WB, ICC, IF, IHC, IP | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0837-FY-F(E) | Human Anti-IgA Recombinant Antibody; Fab Fragment (HPAB-0837-FY-F(E)) | ELISA | Human Fab |
HPAB-0517-WJ-S(P) | Mouse Anti-IgA Recombinant Antibody; scFv Fragment (HPAB-0517-WJ-S(P)) | ELISA | Mouse scFv |
HPAB-0518-WJ-S(P) | Mouse Anti-IgA Recombinant Antibody; scFv Fragment (HPAB-0518-WJ-S(P)) | ELISA | Mouse scFv |
HPAB-0709-WJ-S(P) | Human Anti-IgA Recombinant Antibody; scFv Fragment (HPAB-0709-WJ-S(P)) | ELISA | Human scFv |
FAMAB-0209WJ-S(P) | Mouse Anti-IgA Recombinant Antibody (clone IL-A71); scFv Fragment | ELISA, WB | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0837-FY-S(P) | Human Anti-IgA Recombinant Antibody; scFv Fragment (HPAB-0837-FY-S(P)) | ELISA | Human scFv |
HPAB-0517-WJ-F(E) | Mouse Anti-IgA Recombinant Antibody; Fab Fragment (HPAB-0517-WJ-F(E)) | ELISA | Mouse Fab |
HPAB-0518-WJ-F(E) | Mouse Anti-IgA Recombinant Antibody; Fab Fragment (HPAB-0518-WJ-F(E)) | ELISA | Mouse Fab |
HPAB-0709-WJ-F(E) | Human Anti-IgA Recombinant Antibody; Fab Fragment (HPAB-0709-WJ-F(E)) | ELISA | Human Fab |
HPAB-0710-WJ-F(E) | Human Anti-IgA Recombinant Antibody; Fab Fragment (HPAB-0710-WJ-F(E)) | ELISA | Human Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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