This c-Jun specific binding protein (Z-domain of protein A) was investigated by an α-helix shuffling strategy. The primary scaffold protein was from a naive combinatorial library of the three-helix bundle Z domain derived from staphylococcal protein A. A hierarchical library was constructed through selective re-randomization of six amino acid positions in one of the two α-helices of the domain, making up the Taq DNA polymerase binding surface. After selections using monovalent phage display technology, second generation variants were identified having affinities (KD=5 mM) for c-Jun as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
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CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0043MZ | Chicken Anti-AP-1 Polyclonal IgY | WB | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1902 | Hi-Affi™ Recombinant Rabbit Anti-JUN Monoclonal Antibody (DS1902AB) | IP, WB | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-0365-CN | Recombinant Rabbit Anti-JUN Monoclonal Antibody (CBACN-148) | WB, IF, IHC, IP | Rabbit IgG |
ZG-0782J | Rabbit Anti-JUN Recombinant Antibody (clone 4A11) | ELISA, WB, IHC, IF | Rabbit IgG |
ZG-0783J | Rabbit Anti-JUN Recombinant Antibody (clone 10D4) | ELISA, WB, IHC | Rabbit IgG |
VS3-QX619 | Mouse Anti-JUN Recombinant Antibody (clone 10G2-2G3-1F4) | IHC | Mouse IgG1 |
VS3-QX620 | Mouse Anti-JUN Recombinant Antibody (clone 6A3-7A8-8H3) | IHC | Mouse IgG1 |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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