A*01:01/HCV polyprotein (ATDALMTGY) MHC Monomer (CAT#: MHC-YF151)
This product is a MHC monomer of biotinylated peptide/MHC complex composed polyprotein-derived peptide of ATDALMTGY sequence and A*01:01 molecule. The pMHC monomer recognizes human CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.
Specific Inquiry
Specifications
- Allele
- A*01:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- polyprotein
- Antigen Species
- HCV
- Peptide
- ATDALMTGY
- Conjugate
- Biotin
- Application
- MHC Multimer
Target
- Antigen Introduction
- Core protein packages viral RNA to form a viral nucleocapsid, and promotes virion budding. Modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit. Also regulates many host cellular functions such as signaling pathways and apoptosis. Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by inducing human STAT1 degradation. Thought to play a role in virus-mediated cell transformation leading to hepatocellular carcinomas. Interacts with, and activates STAT3 leading to cellular transformation. May repress the promoter of p53, and sequester CREB3 and SP110 isoform 3/Sp110b in the cytoplasm. Also represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle regulation.
- Alternative Names
- polyprotein
- Gene ID
- 951475
- UniProt ID
- P26662
Downloads
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MHC Tetramer for Virology
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF080 | DRB1*01:01/HCV polyprotein, NS4b (TLLFNILGGWVAA) MHC Monomer | MHC Multimer | |
| MHC-YF081 | DRB1*03:01/HCV polyprotein, NS5b (VYYLTRDPTTPLARAA) MHC Monomer | MHC Multimer | |
| MHC-YF082 | DRB1*04:01/HCV polyprotein, NS3 (GYKVLVLNPSVAATL) MHC Monomer | MHC Multimer | |
| MHC-YF083 | DRB1*04:01/HCV polyprotein, NS4b (SGIQYLAGLSTLPGNPAIASL) MHC Monomer | MHC Multimer | |
| MHC-YF084 | DRB1*15:01/HCV polyprotein, NS3 (GINAVAYYRGLDVSV) MHC Monomer | MHC Multimer |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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