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A*02:01/Human TACE (YLIELIDRV) MHC Pentamer (CAT#: MHC-YF732)

MHC pentamers have a high avidity for CD8 T cells, and can be used in the analysis of individual antigen-specific T cells. This product is a MHC pentamer of peptide/MHC complex composed TACE-derived peptide of YLIELIDRV sequence covering 250-258 and A*02:01 molecule. The peptide/MHC pentamer provided here is unlabelled or fluorescent labelled, such as Biotin, R-PE, APC. All products are available in 50, 150 and 500 tests.


See more MHC Tetramer products for ADAM17
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  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10738/if_selected.jpg
Figure 2 IF staining of human cell line U-251 MG
Figure 2 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/51575/if_selected.jpg
Normal Tissue
Figure 3 IHC staining of human small intestine
Figure 3 IHC staining of human small intestine
(Immunohistochemical staining of human small intestine shows membranous and cytoplasmic positivity.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10738/ihc_selected.jpg
Figure 4 Cerebral cortex
Figure 4 Cerebral cortex
(Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10738/26587_B_8_5.jpg
Figure 5 Colon
Figure 5 Colon
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10738/26587_A_7_3.jpg
Figure 6 Liver
Figure 6 Liver
(Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10738/26587_A_9_4.jpg
Figure 7 Kidney
Figure 7 Kidney
(Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10738/26587_A_7_5.jpg
Figure 8 Testis
Figure 8 Testis
(Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10738/26587_A_4_6.jpg
Figure 9 Placenta
Figure 9 Placenta
(Trophoblastic cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10738/26587_A_2_7.jpg
Figure 10 Lymph node
Figure 10 Lymph node
(Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10738/26587_A_9_8.jpg
RNA Expression
Figure 11 RNA cell line category: Low cell line specificity
Figure 11 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000151694-ADAM17

Specifications

  • Allele
  • A*02:01
  • Class
  • Class I
  • Antigen
  • TACE
  • Antigen Species
  • Human
  • Peptide
  • YLIELIDRV
  • Range
  • 250-258
  • Conjugate
  • Unlabeled, Biotin, R-PE, APC
  • Application
  • FCM

Target

  • Antigen Introduction
  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease. [provided by RefSeq, Feb 2016]
  • Alternative Names
  • ADAM Metallopeptidase Domain 17; Tumor Necrosis Factor, Alpha, Converting Enzyme; Snake Venom-Like Protease; TNF-Alpha Convertase; EC 3.4.24.86; TACE; CSVP; Disintegrin And Metalloproteinase Domain-Containing Protein 17; ADAM Metallopeptidase Domain 18;

Downloads

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See other products for "ADAM17"

Recombinant Antibody

CAT Product Name Application Type
MOB-38 Recombinant Anti-human ADAM17 Antibody ELISA, WB, FC, FuncS IgG
MHH-38 Recombinant Human Anti-human ADAM17 Antibody ELISA, IP, FuncS IgG
MOB-0437MZ Mouse Anti-ADAM17 Recombinant Antibody (clone 1F6) FC, IF, IHC-P, WB Mouse IgG
MRO-0030-CN Rabbit Anti-ADAM17 Recombinant Antibody (clone JM10-35) WB, IF, IP, FC Rabbit IgG
ZG-0529J Rabbit Anti-ADAM17 Recombinant Antibody (clone 5A1) ELISA, IF Rabbit IgG

Fab Fragment Antibody

CAT Product Name Application Type
MOB-38-F(E) Recombinant Anti-human ADAM17 Antibody Fab Fragment ELISA, WB, FuncS Fab
MHH-38-F(E) Recombinant Human Anti-human ADAM17 Antibody Fab Fragment ELISA, WB, IF, FuncS Fab

scFv Fragment Antibody

CAT Product Name Application Type
MOB-38-S(P) Recombinant Anti-human ADAM17 Antibody scFv Fragment ELISA, WB, IP, FuncS scFv
MHH-38-S(P) Recombinant Human Anti-human ADAM17 Antibody scFv Fragment IP, IF, Biosensors, FuncS scFv

Mouse Antibody

CAT Product Name Application Type
TAB-0444CL Anti-Human ADAM17 Recombinant Antibody (ml022C3) ELISA, Inhib, FuncS
TAB-0444CL-S(P) Anti-Human ADAM17 Recombinant Antibody scFv Fragment (ml022C3) ELISA, Inhib, FuncS
TAB-0444CL-F(E) Anti-Human ADAM17 Recombinant Antibody Fab Fragment (ml022C3) ELISA, Inhib, FuncS

Chimeric Antibody

CAT Product Name Application Type
TAB-0445CL Anti-Human ADAM17 Recombinant Antibody (cl022C3) ELISA, Inhib, FuncS Chimeric (mouse/human)
TAB-0445CL-S(P) Anti-Human ADAM17 Recombinant Antibody scFv Fragment (cl022C3) ELISA, Inhib, FuncS Chimeric (mouse/human)
TAB-0445CL-F(E) Anti-Human ADAM17 Recombinant Antibody Fab Fragment (cl022C3) ELISA, Inhib, FuncS Chimeric (mouse/human)

Humanized Antibody

CAT Product Name Application Type
TAB-0446CL Anti-Human ADAM17 Recombinant Antibody (hzl022C3) ELISA, Inhib, FuncS Humanized Antibody
TAB-0446CL-S(P) Anti-Human ADAM17 Recombinant Antibody scFv Fragment (hzl022C3) ELISA, Inhib, FuncS Humanized Antibody
TAB-0446CL-F(E) Anti-Human ADAM17 Recombinant Antibody Fab Fragment (hzl022C3) ELISA, Inhib, FuncS Humanized Antibody

Human Antibody

CAT Product Name Application Type
TAB-0447CL Anti-Human ADAM17 Recombinant Antibody (hl022C3) ELISA, Inhib, FuncS Human antibody
TAB-0447CL-S(P) Anti-Human ADAM17 Recombinant Antibody scFv Fragment (hl022C3) ELISA, Inhib, FuncS Human antibody
TAB-0447CL-F(E) Anti-Human ADAM17 Recombinant Antibody Fab Fragment (hl022C3) ELISA, Inhib, FuncS Human antibody
TAB-0669CLV Anti-Human ADAM17 Recombinant Antibody (D1(A12)) ELISA, PK, Inhib, IHC Human antibody

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0070 Hi-Affi™ Rabbit Anti-ADAM17 Recombinant Antibody (clone DS70AB) WB, IF, IP, FC Rabbit IgG

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-CN0393 PE-A*02:01/Human ADAM17 (YLIELIDRV) MHC Tetramer FCM, IHC
MHC-CN0394 APC-A*02:01/Human ADAM17 (YLIELIDRV) MHC Tetramer FCM, IHC
MHC-CN0395 FITC-A*02:01/Human ADAM17 (YLIELIDRV) MHC Tetramer FCM, IHC
MHC-CN0396 A*02:01/Human ADAM17 (YLIELIDRV) MHC Tetramer FCM, IHC

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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